{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:58:34Z","timestamp":1787061514312,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During examination of cases of chilblains in children and adolescents, we identified four patients who also showed skin lesions similar to erythema multiforme (EM). They had no other known triggers for EM. One of them had a positive PCR for SARS\u2010CoV\u20102, while the other three were negative. Skin biopsies from two patients showed features not typical of EM, such as deep perivascular and perieccrine infiltrate and absence of necrosis of keratinocytes. Immunohistochemistry for SARS\u2010CoV\/SARS\u2010CoV\u20102 spike protein showed granular positivity in endothelial cells and epithelial cells of eccrine glands in both biopsies. All patients had an excellent outcome, and had minimal or no systemic symptoms. The coincidence of EM, a condition commonly related to viruses, and chilblains in the setting of COVID\u201019, and the positivity for SARS\u2010CoV\/SARS\u2010CoV\u20102 spike protein by immunohistochemistry strongly suggest a link between EM\u2010like lesions and SARS\u2010CoV\u20102.<\/jats:p>","DOI":"10.1111\/pde.14246","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T15:10:46Z","timestamp":1590246646000},"page":"442-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Erythema multiforme\u2010like lesions in children and COVID\u201019"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-6916","authenticated-orcid":false,"given":"Antonio","family":"Torrelo","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid 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