{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:35:32Z","timestamp":1764570932443,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>BRAF inhibitor\u2010induced neutrophilic panniculitis is a rare event that is well\u2010characterized in adults undergoing therapy for metastatic melanoma. To date, there are very few reports of this event in children undergoing BRAF inhibitor therapy for low\u2010grade gliomas, all of which were seen with vemurafenib. We report a case of dabrafenib\u2010induced neutrophilic panniculitis in a 9\u2010year\u2010old girl that manifested within several weeks of initiating dual BRAF\u2010MEK inhibitor therapy for glioblastoma multiforme. This case highlights neutrophilic panniculitis as a side effect of dabrafenib in children and serves as a reminder to consider cutaneous side effects of BRAF inhibitors as they are increasingly used to treat children with primary brain tumors.<\/jats:p>","DOI":"10.1111\/pde.14306","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T10:06:58Z","timestamp":1598954818000},"page":"1185-1186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dabrafenib\u2010induced neutrophilic panniculitis in a child undergoing dual BRAF\u2010MEK inhibitor therapy for glioblastoma multiforme"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0215-9886","authenticated-orcid":false,"given":"Trevor K.","family":"Young","sequence":"first","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maressa C.","family":"Criscito","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randie H.","family":"Kim","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8122-6145","authenticated-orcid":false,"given":"Nikita","family":"Lakdawala","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikash S.","family":"Oza","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology New York University Grossman School of Medicine New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27682"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13039"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13148"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12316"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000461571"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.14306","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T19:39:23Z","timestamp":1693337963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.14306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/pde.14306"],"URL":"https:\/\/doi.org\/10.1111\/pde.14306","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"2020-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}