{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:00:48Z","timestamp":1790618448179,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (HS), characterized by inflammatory nodules, sinus tracts, and abscesses, has been linked to several factors, including immune dysfunction and obesity, which are thought to contribute to its development. Several follicular disorders have also been associated with Down syndrome (DS), a common chromosomal disorder, including HS, although studies on this topic are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize HS in Down syndrome patients and to further examine the association between HS and DS compared to HS patients without DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically searched MEDLINE, Embase, Web of Science, and CENTRAL electronic databases from their dates of conception to February 2020. Random\u2010effects meta\u2010analyses were performed analyzing (a) HS characteristics between DS and non\u2010DS participants, and (b) prevalence or association between HS and DS compared to non\u2010DS individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies were included in this systematic review, with a total of 358 participants presenting with both HS and DS. Pooled analysis of mean differences between DS and non\u2010DS participants presenting with HS found a significantly younger age of HS symptom onset for DS patients (\u22126.24; 95% CI, \u221210.01\u2010\u22122.24). A meta\u2010analysis examining the association between HS and DS found a significantly increased likelihood of HS in DS patients (OR 9.61; 95% CI, 5.70\u201016.20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest an association between HS and DS, with DS patients suffering from an earlier onset of HS symptoms compared to non\u2010DS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.14326","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T12:19:42Z","timestamp":1599394782000},"page":"1044-1050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Hidradenitis suppurativa and Down syndrome: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5819-7684","authenticated-orcid":false,"given":"Megan","family":"Lam","sequence":"first","affiliation":[{"name":"Michael G. DeGroote School of Medicine McMaster University Hamilton ON Canada"},{"name":"Faculty of Science University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charis","family":"Lai","sequence":"additional","affiliation":[{"name":"Faculty of Science University of Western Ontario London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouf","family":"Almuhanna","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"},{"name":"King Fahd Medical City Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Alhusayen","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"},{"name":"Division of Dermatology Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.911"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.06.013"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065859"},{"key":"e_1_2_5_6_1","unstructured":"U.S. Department of Health and Human Services National Institutes of Health National Heart Lung and Blood Institute (NIH).Assessing cardiovascular risk \u2013 Systematic evidence review from the risk assessment work group.https:\/\/www.nhlbi.nih.gov\/health\u2010topics\/study\u2010quality\u2010assessment\u2010tools. 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