{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:33:02Z","timestamp":1791977582501,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various monotherapies exist for tinea capitis; however, their relative efficacies have never been determined using a statistical approach which compares treatments\u2019 efficacy simultaneously. The goal of this study was to determine the relative efficacy (mycologic and complete cure rates) of monotherapies for the treatment of tinea capitis. On October 5, 2019, searches were performed in Scopus, PubMed, EMBASE, MEDLINE (Ovid), and CINAHL; there were no date restrictions. For the main network meta\u2010analysis, eligible studies were randomized trials that investigated the effect of tinea capitis monotherapies on subjects\u2019 mycological and complete cure rates. Network meta\u2010analyses were conducted in accordance with the 2015 Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses checklist for network meta\u2010analyses. Mycological cure rate was the primary outcome; complete cure rate and adverse events were secondary outcomes. Twelve studies met the eligibility criteria for the main network; five systemic monotherapies were identified, griseofulvin, ketoconazole, terbinafine, itraconazole, and fluconazole. When the causative species was of the <jats:italic>Microsporum<\/jats:italic> genus, griseofulvin was most efficacious in terms of mycological cure (SUCRA\u00a0=\u00a066.1%) and complete cure (SUCRA\u00a0=\u00a080.6%). For tinea capitis caused by the <jats:italic>Trichophyton<\/jats:italic> species, terbinafine was the most efficacious in terms of both mycological and complete cure (SUCRA values of 75.2% and 78.2%, respectively). Risk of adverse events did not significantly differ across the interventions. Our results are congruent with those of previous pairwise meta\u2010analyses; our findings also corroborate clinical experience and anecdotal evidence.<\/jats:p>","DOI":"10.1111\/pde.14353","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T07:10:01Z","timestamp":1600931401000},"page":"1014-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A network meta\u2010analysis on the efficacy and safety of monotherapies for tinea capitis, and an assessment of evidence quality"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mediprobe Research Inc.  London ON Canada"},{"name":"Division of Dermatology Department of Medicine University of Toronto School of Medicine  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Bamimore","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc.  London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen J.","family":"Renaud","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc.  London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil H.","family":"Shear","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Toronto School of Medicine  Toronto ON Canada"},{"name":"Division of Dermatology Sunnybrook Health Sciences Centre  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Piguet","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Toronto School of Medicine  Toronto ON Canada"},{"name":"Division of Dermatology Women's College Hospital  Toronto ON Canada"},{"name":"Division of Infection and Immunity Cardiff University School of Medicine  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.1862000.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90013-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546639909056027"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.01978.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.019"},{"key":"e_1_2_5_7_1","unstructured":"The Cochrane Collaboration.Review Manager(RevMan). 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