{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T23:45:24Z","timestamp":1780789524147,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Oncology patients present with various skin manifestations related to primary disease and treatments. Although these skin toxicities are well described in adults, studies of pediatric oncology patients are limited. The objective of this study was to evaluate the cutaneous findings in pediatric oncology patients receiving chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cohort study conducted from December 2018 to March 2020, all pediatric oncology patients were examined and patients who had a dermatologic finding at any point during their treatments were recorded. Dermatologic examinations were performed by the same dermatologists, and biopsy and microbiologic tests were performed according to clinical need. Patients were grouped according to their oncologic diagnoses and types of chemotherapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 80 patients with a mean age of 9.1\u00a0\u00b1\u00a05.0\u00a0years were included in the study. Seventy\u2010five (93.7%) of them developed a dermatologic manifestation during the study period. Most of the patients had hematologic malignancies (n\u00a0=\u00a048, 60%). Antimetabolites were the most frequently used class of chemotherapeutic agents. Anagen effluvium was the most common dermatologic finding (61.3%, n\u00a0=\u00a049), followed by inflammatory dermatoses (51.2%, n\u00a0=\u00a041, most commonly diaper dermatitis in 33 patients), xerosis (35%, n\u00a0=\u00a028), and nail changes (20%, n\u00a0=\u00a016, most commonly nail pigmentation in seven patients). Mucositis was seen in 13 (16.2%) patients. Five patients (6.2%) had drug\u2010induced cutaneous hyperpigmentation, and five (6.2%) had toxic erythema of chemotherapy. The highest percentage of xerosis (45.4%) was detected in patients using antitumor antibiotics, whereas inflammatory dermatoses were observed more in patients using antimetabolites (48.6% of patients using antimetabolites), and pigmentation changes were more frequently detected in patients using alkylating agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Identification, diagnosis, and treatment of these reactions are important to dermatologists and oncologists so that appropriate management may be provided to pediatric oncology patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.14375","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T12:54:49Z","timestamp":1605185689000},"page":"58-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cutaneous manifestations in pediatric oncology patients"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9136-7021","authenticated-orcid":false,"given":"Ezgi","family":"\u00d6zkur","sequence":"first","affiliation":[{"name":"Dermatology Department \u015ei\u015fli Hamidiye Etfal Training and Research Hospital University of Health Sciences  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansu","family":"Sert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics \u015ei\u015fli Hamidiye Etfal Training and Research Hospital University of Health Sciences  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lknur","family":"K\u0131van\u00e7 Altunay","sequence":"additional","affiliation":[{"name":"Dermatology Department \u015ei\u015fli Hamidiye Etfal Training and Research Hospital University of Health Sciences  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep Y\u0131ld\u0131z","family":"Y\u0131ld\u0131r\u0131rmak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology \u015ei\u015fli Hamidiye Etfal Training and Research Hospital University of Health Sciences  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dildar Bahar","family":"Gen\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology \u015ei\u015fli Hamidiye Etfal Training and Research Hospital University of Health Sciences  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Vural","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology \u015ei\u015fli Hamidiye Etfal Training and Research Hospital University of Health Sciences  \u0130stanbul 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