{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:25:34Z","timestamp":1776471934573,"version":"3.51.2"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T00:00:00Z","timestamp":1603497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dermatologically, <jats:italic>FGFR3<\/jats:italic> mutations can lead to acanthosis nigricans (AN), epidermal nevi, and seborrheic keratosis. A recent case report found that topical rapamycin (sirolimus) can improve <jats:italic>FGFR3<\/jats:italic>\u2010induced epidermal nevi with AN features in children, specifically with Fitzpatrick skin type (FST) I\/II, and we would like to expand these findings to skin plaques with extensive AN\u2010like features in the FST IV\/V adolescent population. An 18\u2010year\u2010old female with FST IV\/V and <jats:italic>FGFR3<\/jats:italic>\u2010induced hypochondroplasia presented to our clinic with extensive AN\u2010like plaques. Significant improvement with lightening and thinning of the plaques was observed after applying 1% topical rapamycin cream twice daily. Topical rapamycin should be considered as a treatment option for AN, particularly in FST IV\/V adolescents with <jats:italic>FGFR3<\/jats:italic>\u2010induced AN.<\/jats:p>","DOI":"10.1111\/pde.14404","type":"journal-article","created":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T06:48:40Z","timestamp":1603608520000},"page":"296-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Topical rapamycin for acanthosis nigricans in the Fitzpatrick IV\/V adolescent population"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0631-9779","authenticated-orcid":false,"given":"Kathleen M.","family":"Coerdt","sequence":"first","affiliation":[{"name":"Georgetown University School of Medicine  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah P.","family":"Todd","sequence":"additional","affiliation":[{"name":"Department of Dermatology MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia M. C.","family":"DeKlotz","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine  Washington DC USA"},{"name":"Department of Dermatology MedStar Georgetown University Hospital  Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,24]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13061"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13833"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05150.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.137765"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680170073009"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14404","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.14404","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T17:31:00Z","timestamp":1693675860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.14404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,24]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/pde.14404"],"URL":"https:\/\/doi.org\/10.1111\/pde.14404","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,24]]},"assertion":[{"value":"2020-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}