{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:49:22Z","timestamp":1785268162436,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Patients with epidermolysis bullosa (EB) require care of wounds that are colonized or infected with bacteria. A subset of EB patients are at risk for squamous cell carcinoma, and bacterial\u2010host interactions have been considered in this risk. The EB Clinical Characterization and Outcomes Database serves as a repository of information from EB patients at multiple centers in the United States and Canada. Access to this resource enabled broad\u2010scale analysis of wound cultures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 739 wound cultures from 158 patients from 13 centers between 2001 and 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 152 patients with a positive culture, <jats:italic>Staphylococcus aureus<\/jats:italic> (SA) was recovered from 131 patients (86%), <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (PA) from 56 (37%), and <jats:italic>Streptococcus pyogenes<\/jats:italic> (GAS) from 34 (22%). Sixty\u2010eight percent of patients had cultures positive for methicillin\u2010sensitive SA, and 47%, methicillin\u2010resistant SA (18 patients had cultures that grew both methicillin\u2010susceptible and methicillin\u2010resistant SA at different points in time). Of 15 patients with SA\u2010positive cultures with recorded mupirocin susceptibility testing, 11 had mupirocin\u2010susceptible SA and 6 patients mupirocin\u2010resistant SA (2 patients grew both mupirocin\u2010susceptible and mupirocin\u2010resistant SA). SCC was reported in 23 patients in the entire database, of whom 10 had documented wound cultures positive for SA, PA, and <jats:italic>Proteus<\/jats:italic> species in 90%, 50%, and 20% of cases, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SA and PA were the most commonly isolated bacteria from wounds. Methicillin resistance and mupirocin resistance were reported in 47% and 40% of patients tested, respectively, highlighting the importance of ongoing antimicrobial strategies to limit antibiotic resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.14444","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T08:41:30Z","timestamp":1606552890000},"page":"119-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Characterization of wound microbes in epidermolysis bullosa: Results from the epidermolysis bullosa clinical characterization and outcomes database"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-6585","authenticated-orcid":false,"given":"Laura E.","family":"Levin","sequence":"first","affiliation":[{"name":"Department of Dermatology Columbia University Irving Medical Center New York NY 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University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Feinstein","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Whittier","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-4831","authenticated-orcid":false,"given":"Christine T.","family":"Lauren","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Dermatology Columbia University Irving Medical Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pope","sequence":"additional","affiliation":[{"name":"Section of Dermatology Division of Paediatric Medicine Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-3413","authenticated-orcid":false,"given":"Irene","family":"Lara\u2010Corrales","sequence":"additional","affiliation":[{"name":"Section of Dermatology Division of Paediatric Medicine Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-6503","authenticated-orcid":false,"given":"Karen","family":"Wiss","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-6247","authenticated-orcid":false,"given":"Catherine C.","family":"McCuaig","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Dermatology CHU Sainte\u2010Justine University of Montreal Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Sainte\u2010Justine University of Montreal Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence F.","family":"Eichenfield","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Dermatology University of California San Diego San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moise L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Dermatology Dell Children\u2019s Medical Center Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dell Children's Medical Center Austin TX 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