{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:49:49Z","timestamp":1781614189350,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent angioedema is a rare entity during childhood. This study aimed to clarify differences between hereditary angioedema (HAE) and histaminergic angioedema (HA) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010seven children with HAE (male 36.8%, 8.9\u00a0years [5.4\u201012.5]) and 42 children with recurrent HA (male 42.9%, 11.5\u00a0years [8.1\u201016.8]) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age at symptom onset (6 [3\u201010]; 7.8 [4.5\u201013] years), frequency of angioedema episodes within last year (3 [2\u20105]; 5 [2\u201010]), and duration of symptoms (48 [24\u201048]; 24 [12\u201048] hours) were similar in the HAE and HA group, respectively. Recurrent urticaria was observed in 7.3% (n\u00a0=\u00a03) of patients in the HAE group and in 45.2% (n\u00a0=\u00a019) of the HA group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). While angioedema episodes involving the lips (n\u00a0=\u00a030; 71.4%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.035) and eyelids (n\u00a0=\u00a028; 66.7%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.012) were observed more frequently in the HA group, gastrointestinal involvement\/abdominal pain (n\u00a0=\u00a015; 36.6%) was more common in HAE (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Itching as a prodromal symptom was detected in 47.6% (n\u00a0=\u00a020) of HA patients versus 14.6% (n\u00a0=\u00a06) of those with HAE (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). In the logistic regression analysis for the diagnosis of HAE, a family history of angioedema (OR\u00a0=\u00a058.289 [95% CI 10.656\u2010318.853], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0001) and trauma (OR\u00a0=\u00a035.208 [95% CI [4.368\u2010283.794]], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) as a triggering factor were determined to be independent variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A family history of angioedema, trauma as a triggering factor, and abdominal pain should suggest the diagnosis of HAE and the need for further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.14467","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T15:02:46Z","timestamp":1607094166000},"page":"143-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recurrent angioedema in childhood: hereditary angioedema or histaminergic angioedema?"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7841-4690","authenticated-orcid":false,"given":"Melike","family":"Ocak","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercan","family":"Nain","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Sanliurfa Training and Research Hospital  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-913X","authenticated-orcid":false,"given":"\u00dcmit Murat","family":"\u015eahiner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa \u015eenol","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Karabiber","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Sanliurfa Training and Research Hospital  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7402-6850","authenticated-orcid":false,"given":"B\u00fclent Enis","family":"\u015eekerel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-251X","authenticated-orcid":false,"given":"\u00d6zge","family":"Soyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy Hacettepe University Faculty of 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