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Some patients display features of congestive heart failure and rapidly deteriorate; others exhibit no evident warning signs until sudden death reveals underlying heart disease. We present two patients to illustrate the characteristic hair, skin, teeth, and nail abnormalities, which\u2014especially when distinct from that of other family members\u2014should prompt cardiac evaluation and genetic analysis. In this article, we discuss established treatments as well as a promising, novel therapeutic that has led to nearly complete resolution of the cutaneous and cardiac pathology in EKC syndrome.<\/jats:p>","DOI":"10.1111\/pde.14478","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T14:22:58Z","timestamp":1607091778000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hair and skin predict cardiomyopathies: Carvajal and erythrokeratodermia cardiomyopathy syndromes"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-5441","authenticated-orcid":false,"given":"Qisi","family":"Sun","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Genetics, and Pathology Yale School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Wine 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