{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:06:50Z","timestamp":1787166410269,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute generalized exanthematous pustulosis (AGEP) is a rare, severe, cutaneous adverse reaction. Although most commonly caused by drugs, it can also be triggered by infections, especially in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective study involving children and adolescents aged 16\u00a0years or younger, diagnosed with AGEP between January 2010 and March 2020 in our tertiary pediatric hospital. Information pertaining to the patient's demographics, clinical presentation and progress, biochemical, microbiological, and histopathological investigations, treatment, and outcomes was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight patients were diagnosed with AGEP with mean age 8.2\u00a0years (range: 1.7\u201016.0\u00a0years). None of the patients had a personal or family history of psoriasis. Almost all patients had fever (n\u00a0=\u00a07, 87.5%). Although all 8 patients had intercurrent illness, 5 cases were attributed to infection, while the other 3 were likely precipitated by drugs. Abnormal hematological and biochemical parameters included a raised absolute neutrophil count (mean: 11.5\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L, range: 5.0\u201030.9\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L), C\u2010reactive protein (mean: 52.5\u00a0mg\/L, range: 5.0\u2010143.7\u00a0mg\/L), and erythrocyte sedimentation rate (mean: 38.6\u00a0mm\/h, range: 6\u201064\u00a0mm\/h). All patients developed post\u2010pustular desquamation and subsequently recovered. The mean duration from onset to cessation of acute pustulation was 5.6\u00a0days (range: 3.0\u201010.0\u00a0days). One patient developed a recurrent episode of AGEP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AGEP is rare and may be more commonly caused by infections in children. The condition is self\u2010limiting with overall good outcomes in this age\u2010group. In cases with concomitant infection and drug use, formal allergy testing should be arranged after resolution of the infection to confirm the underlying etiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.14482","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T11:36:28Z","timestamp":1608291388000},"page":"424-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Acute generalized exanthematous pustulosis in children and adolescents in Singapore: A ten\u2010year retrospective review"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-8370","authenticated-orcid":false,"given":"Elis Yuexian","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Paediatric Medicine KK Women\u2019s and Children\u2019s Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-4105","authenticated-orcid":false,"given":"Mark Jean Aan","family":"Koh","sequence":"additional","affiliation":[{"name":"Dermatology Service KK Women\u2019s and Children\u2019s Hospital Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500406"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028003113.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.163"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.9.1172"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13967"},{"key":"e_1_2_7_8_1","first-page":"S38","article-title":"HLA et pr\u00e9disposition g\u00e9n\u00e9tique dans les pustuloses exanth\u00e9matiques aigu\u00ebs g\u00e9n\u00e9ralis\u00e9es (PEAG) et dans les exanth\u00e8mes maculo\u2010papuleux (EMP)","volume":"122","author":"Bernard P","year":"1995","journal-title":"Ann Dermatol Venerol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3848"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.44"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.2151"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14259"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2014.09.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-017-1043-0"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15175"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.0357"},{"issue":"4","key":"e_1_2_7_18_1","first-page":"497","article-title":"Clinical analysis of childhood acute generalized exanthematous pustulosis","volume":"10","author":"Zhang JL","year":"2008","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"e_1_2_7_19_1","first-page":"220","article-title":"Acute generalized exanthematous pustulosis associated to Epstein Barr. A propos of a case","volume":"89","author":"Scaglione AL","year":"2008","journal-title":"Rev Argent Dermatol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.01001.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13827"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01612.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2013.12.004"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.02.013"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680080069004"},{"issue":"1","key":"e_1_2_7_26_1","first-page":"88","article-title":"Pediatric acute generalized exanthematous pustulosis involving Staphylococcal scarlet fever","volume":"5","author":"Henry SM","year":"2019","journal-title":"Med Case Rep"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13434"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00346.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.14482","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T15:28:08Z","timestamp":1692286088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.14482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/pde.14482"],"URL":"https:\/\/doi.org\/10.1111\/pde.14482","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,18]]},"assertion":[{"value":"2020-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}