{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:07:46Z","timestamp":1791356866856,"version":"4.3.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nevus comedonicus (NC) syndrome is a condition first identified in 1978. The cause of NC syndrome has been recently proven to be a gain\u2010of\u2010function, mosaic postzygotic mutation of the <jats:italic>NEK9<\/jats:italic> gene. A systematic review of the literature retrieved 43 well\u2010established cases of NC syndrome reported so far. Three morphological variants of NC in NC syndrome emerged: (a) the more common, predominantly comedonal type; (b) \u201cSelhorst type\u201d; and (c) \u201catrophoderma vermiculatum\u201d type. NC syndrome is mainly associated with ocular, skeletal, and neural abnormalities, most typically ipsilateral congenital cataract and malformations of fingers and toes.<\/jats:p>","DOI":"10.1111\/pde.14508","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T02:35:55Z","timestamp":1611369355000},"page":"359-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Nevus comedonicus syndrome: A systematic review of the literature"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-5222","authenticated-orcid":false,"given":"Daniele","family":"Torchia","sequence":"first","affiliation":[{"name":"Department of Dermatology James Paget University Hospital Great Yarmouth 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