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Cutaneous necrosis, first described in an SMA mouse model, can occur in patients with severe disease; the use of targeted treatment versus supportive measures in the setting of skin necrosis is debated. We present a male infant with SMA type 0 with cutaneous necrosis of proximal and distal limbs who improved with supportive care. The seven previously reported cases of SMA skin necrosis are reviewed.<\/jats:p>","DOI":"10.1111\/pde.14538","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T09:36:16Z","timestamp":1614072976000},"page":"632-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Skin necrosis in spinal muscular atrophy: Case report and review of the literature"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-1995","authenticated-orcid":false,"given":"Amanda S.","family":"Weissman","sequence":"first","affiliation":[{"name":"Medical College of Georgia Augusta University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey R.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical College of Georgia Augusta University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Georgia Augusta University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loretta S.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical College of Georgia Augusta University Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90460-3"},{"key":"e_1_2_5_3_1","unstructured":"SMN2 gene: MedlinePlus Genetics.MedlinePlus.https:\/\/medlineplus.gov\/genetics\/gene\/smn2\/. 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