{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T09:28:14Z","timestamp":1748424494252,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tinea capitis is a common fungal infection in Israel, most commonly caused by the dermatophyte <jats:italic>Trichophyton tonsurans<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the effectiveness of oral antifungal monotherapy in producing clinical or complete cure. We also evaluated the impact of topical therapy (bifonazole 1% shampoo and\/or betamethasone valerate 0.1% solution), prior to oral treatment, on patients' likelihood of clinical or complete cure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was conducted. Patients with mycologically confirmed tinea capitis were treated with one of four regimens: (1) terbinafine (greater than 40\u00a0kg: 250\u00a0mg\/day, 20 to 40\u00a0kg: 125\u00a0mg\/day, less than 20\u00a0kg: 62.5\u00a0mg\/day), (2) itraconazole 5\u00a0mg\/kg daily, (3) fluconazole 6\u00a0mg\/kg daily, or (4) griseofulvin 20\u00a0mg\/kg daily. We used generalized linear models (GLM) to determine whether there was a significant association between the odds of cure and choice of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The causative species was <jats:italic>Trichophyton tonsurans<\/jats:italic> in all but 6 cases that grew <jats:italic>T<\/jats:italic> <jats:italic>violaceum<\/jats:italic>. For pediatric patients, the odds of having complete or clinical cure within 6\u00a0weeks was greater if they used terbinafine compared to itraconazole, fluconazole, or griseofulvin (odds ratio [OR]\u00a0=\u00a09.06, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.047). The likelihood of complete or clinical cure within 8\u00a0weeks of oral therapy was lower if topical steroids were previously used compared to if topical antifungals were used prior to systemic treatment (OR\u00a0=\u00a00.29, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings substantiate prior literature demonstrating that terbinafine is non\u2010inferior to griseofulvin, itraconazole, and fluconazole in the therapy of pediatric tinea capitis caused by <jats:italic>T tonsurans<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.14572","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T10:14:39Z","timestamp":1621246479000},"page":"806-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Management of tinea capitis in Israel: A comparative study"],"prefix":"10.1111","volume":"38","author":[{"given":"Avner","family":"Shemer","sequence":"first","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Mediprobe Research Inc. London ON Canada"},{"name":"Division of Dermatology Department of Medicine University of Toronto School of Medicine Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eran","family":"Galili","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"Daniel","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center and University of Alabama Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riad","family":"Kassem","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Farhi","sequence":"additional","affiliation":[{"name":"Hospital Nossa Senhora da Saude University Funda\u00e7\u00e3o Tecnico Educacional Souza Marques Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadas","family":"Grunwald","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary A.","family":"Bamimore","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc. London ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14353"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12501"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00436862"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15088"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2004.tb01433.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.01978.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.019"},{"issue":"2","key":"e_1_2_7_9_1","first-page":"161","article-title":"S1 guidelines: Tinea capitis","volume":"18","author":"Mayser P","year":"2020","journal-title":"J Ger Soc Dermatol JDDG"},{"key":"e_1_2_7_10_1","unstructured":"RStudio Team.RStudio: Integrated development environment for R. 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