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Common systemic etiologies include diseases with hepatic, renal, and hematologic origins. This encompasses several congenital liver disorders, end\u2010stage renal disease (ESRD), and lymphoproliferative disorders such as Hodgkin's lymphoma. In this paper, an expert panel describes the clinical characteristics, pathophysiology, and therapeutic treatment ladders for chronic pruritus associated with the aforementioned systemic etiologies. Novel therapies are also reviewed. Our aim is to shed light on this unexplored area of pediatric dermatology and instigate further research.<\/jats:p>","DOI":"10.1111\/pde.14596","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T09:52:36Z","timestamp":1631526756000},"page":"1051-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic causes of non\u2010dermatologic chronic pruritus in the pediatric population and their management: An unexplored area"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2650-7451","authenticated-orcid":false,"given":"Pooja","family":"Gurnani","sequence":"first","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery &amp; Miami Itch Center University of Miami Miller School of Medicine Miami FL USA"},{"name":"Florida International University Herbert Wertheim College of Medicine Miami FL 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