{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:29:29Z","timestamp":1791325769611,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004357","name":"Procter and Gamble","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objective<\/jats:title><jats:p>Newborn infant skin is functional but immature, and diapering products can play a significant role in infant diapered skin health. Previous work demonstrated a regimen consisting of a diaper with an emollient and apertures on the inner liner (topsheet) with an acidic, pH\u2010buffered wipe (Regimen A) lowered newborn skin pH and reduced the enzymatic activity on skin post\u2010stool cleaning versus a regimen without these features (Regimen B). This study extends these findings to determine the impact of Regimen A on diaper area erythema severity over a 2\u2010week use period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This IRB\u2010approved, blinded, randomized, crossover study enrolled newborn infants &gt;7\u00a0days and \u22648\u00a0weeks. Participants exclusively used two unique diaper and wipe combinations, Regimen A and Regimen B (non\u2010emollient, non\u2010aperture containing topsheet and wipe with limited buffering capacity), each for 14\u00a0days and preceded by a 3\u2010day washout regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diapered skin pH was reduced during Regimen A use to values similar to that of a non\u2010diapered control site (chest), while use of Regimen B was associated with a more alkaline skin pH. Regimen A resulted in significantly fewer severe erythema episodes. At the site of highest erythema, the perianal space, the average erythema score was significantly lower and more newborns were free of erythema while using Regimen A vs. Regimen B (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrate that diapering products can have a significant impact on newborn skin. They reinforce the need to support the physiological normalization of skin pH and protection from skin irritation and damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.14602","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T07:33:22Z","timestamp":1622532802000},"page":"768-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Improving newborn skin health: Effects of diaper care regimens on skin pH and erythema"],"prefix":"10.1111","volume":"38","author":[{"given":"Jennifer","family":"Gustin","sequence":"first","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bohman","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Ogle","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Fadayel","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Narendran","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marty O.","family":"Visscher","sequence":"additional","affiliation":[{"name":"James L. Winkle College of Pharmacy University of Cincinnati Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1676-8033","authenticated-orcid":false,"given":"Andrew N.","family":"Carr","sequence":"additional","affiliation":[{"name":"The Procter and Gamble Company Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.nainr.2014.10.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31002-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01710.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1608708"},{"key":"e_1_2_9_6_1","first-page":"75","article-title":"Etiology and pathophysiology of diaper dermatitis","volume":"3","author":"Berg RW","year":"1988","journal-title":"Adv Dermatol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00066.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138117"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12501"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12819"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328744"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14169"},{"key":"e_1_2_9_13_1","unstructured":"Honest Company.https:\/\/www.honest.com\/baby\u2010products\/honest\u2010diapers\/baby\u2010diapers.html. 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