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Also, the topical use of a commercially available sirolimus solution approved for oral administration is described regularly. To better guide providers in their decision\u2010making when topical sirolimus is being considered, this article highlights the substantial pharmaceutical and clinical differences between commercial oral solution and compounded preparations specifically designed for topical therapy.<\/jats:p>","DOI":"10.1111\/pde.14637","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T07:42:54Z","timestamp":1622533374000},"page":"967-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Topical sirolimus: Difference between compounded preparations and commercial oral solution"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9103-609X","authenticated-orcid":false,"given":"Lars","family":"Brichta","sequence":"first","affiliation":[{"name":"Chemistry Rx Compounding and Specialty Pharmacy Folcroft PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Carver","sequence":"additional","affiliation":[{"name":"Organic Chemistry University of Alabama in Huntsville Huntsville AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia Marie","family":"Carver DeKlotz","sequence":"additional","affiliation":[{"name":"Department of Dermatology MedStar Washington Hospital Center\/Georgetown University Hospital Washington DC USA"},{"name":"Georgetown University School of Medicine Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.0464"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28088"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12458"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13686"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13800"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14404"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13782"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.4083"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12182"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2011.00837.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13547"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13596"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14104"},{"key":"e_1_2_4_15_1","unstructured":"Rapamune (sirolimus) oral solution and tablets FDA\u2010approved label. Wyeth Pharmaceuticals LLC a subsidiary of Pfizer Inc.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/021083s059 021110s076lbl.pdf"},{"key":"e_1_2_4_16_1","unstructured":"Data on file (27). 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