{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:21:29Z","timestamp":1773836489741,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CARD14\u2010associated papulosquamous eruption (CAPE) is a rare autosomal dominant dermatosis that presents classically in early childhood with clinical features of both psoriasis and pityriasis rubra pilaris (PRP). The disease is known to be refractory to topical and systemic therapies classically used for psoriasis, with the majority of reported cases requiring treatment with biologics, such as ustekinumab and secukinumab. We present a toddler with a clinical presentation consistent with CAPE and found to have a novel heterozygous variant of the <jats:italic>CARD14<\/jats:italic> gene. She was refractory to treatment with topical emollients and topical corticosteroids, but responsive to oral acitretin.<\/jats:p>","DOI":"10.1111\/pde.14638","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T07:25:59Z","timestamp":1622618759000},"page":"970-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["CARD14\u2010associated papulosquamous eruption (CAPE) in a toddler responding to treatment with acitretin"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-5180","authenticated-orcid":false,"given":"Gabriel Hong Zhe","family":"Wong","sequence":"first","affiliation":[{"name":"General Medicine Sengkang General Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5005-3499","authenticated-orcid":false,"given":"Shi Yun","family":"Chia","sequence":"additional","affiliation":[{"name":"Paediatric Medicine KK Women\u2019s and Children\u2019s Hospital Singapore Singapore"},{"name":"Dermatology Service KK Women\u2019s and Children\u2019s Hospital Singapore Singapore"},{"name":"Paediatrics Academic Clinical Programme SingHealth Duke\u2010NUS Graduate Medical School Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heming","family":"Wei","sequence":"additional","affiliation":[{"name":"Research Laboratory KK Women's &amp; Children's Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3749-2814","authenticated-orcid":false,"given":"Khadijah","family":"Rafi'ee","sequence":"additional","affiliation":[{"name":"Research Laboratory KK Women's &amp; Children's Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-4105","authenticated-orcid":false,"given":"Mark Jean Aan","family":"Koh","sequence":"additional","affiliation":[{"name":"Dermatology Service KK Women\u2019s and Children\u2019s Hospital Singapore Singapore"},{"name":"Paediatrics Academic Clinical Programme SingHealth Duke\u2010NUS Graduate Medical School Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-6058","authenticated-orcid":false,"given":"Ene Choo","family":"Tan","sequence":"additional","affiliation":[{"name":"Paediatrics Academic Clinical Programme SingHealth Duke\u2010NUS Graduate Medical School Singapore Singapore"},{"name":"Research Laboratory KK Women's &amp; Children's Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13633"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.05.010"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.03.013"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15462"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1309349"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.14638","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:10:19Z","timestamp":1693350619000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.14638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,2]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/pde.14638"],"URL":"https:\/\/doi.org\/10.1111\/pde.14638","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,2]]},"assertion":[{"value":"2021-06-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}