{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:48:19Z","timestamp":1787240899616,"version":"build-2736575974"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We report a case of a 3\u2010year\u2010old girl with generalized pustular psoriasis (GPP) and a compound heterozygous mutation within the IL36 receptor antagonist\n                    <jats:italic>(IL36RN)<\/jats:italic>\n                    gene at c.28C&gt;T and c.115+6T&gt;C, who was successfully treated using secukinumab monotherapy. The first dose of secukinumab (150\u00a0mg) was administered subcutaneously, followed by 75\u00a0mg of secukinumab subcutaneously once weekly for 4\u00a0weeks and then 75\u00a0mg every 4\u00a0weeks. The total course of treatment was 4\u00a0months, with a total of 8 doses. A PASI score of 75 and 100 was achieved at weeks 1 and 2, respectively, and maintained for 11\u00a0months of follow\u2010up, without disease recurrence or adverse events.\n                  <\/jats:p>","DOI":"10.1111\/pde.14795","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T06:45:01Z","timestamp":1631515501000},"page":"1366-1367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Successful treatment of a 3\u2010year\u2010old girl with generalized pustular psoriasis using secukinumab monotherapy"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1940-6572","authenticated-orcid":false,"given":"Huiying","family":"Zhu","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-1175","authenticated-orcid":false,"given":"Pingping","family":"Song","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-5809","authenticated-orcid":false,"given":"Donghong","family":"Du","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-927X","authenticated-orcid":false,"given":"Hongqing","family":"Tian","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15228"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15673"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14636"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2021.1899111"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex510"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.14795","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:08:53Z","timestamp":1696522133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.14795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/pde.14795"],"URL":"https:\/\/doi.org\/10.1111\/pde.14795","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"2021-09-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}