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Clinical assessment, histopathologic, cytogenetic, and molecular genetic investigations on affected cells were pursued. Histopathology confirmed PEODDN, and chromosomal microarray on affected tissues identified a mosaic 3p26.3p25.3 deletion in affected tissues. This 11Mb deletion encompasses 47 OMIM genes. We propose that this and other chromosomal deletions may be implicated in some cases of PEODDN, suggesting locus heterogeneity and underscoring the importance of incorporating cytogenetic and molecular investigations into the multidisciplinary care of individuals with suspected mosaic genetic skin disorders.<\/jats:p>","DOI":"10.1111\/pde.14850","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:08:43Z","timestamp":1640045323000},"page":"107-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Porokeratotic eccrine ostial and dermal duct nevus associated with an 11 megabase 3p deletion"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1138-5044","authenticated-orcid":false,"given":"Alison M. 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