{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:14:39Z","timestamp":1759335279089,"version":"3.40.5"},"reference-count":4,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary erythromelalgia is a rare autosomal\u2010dominant condition due to pathogenic variant in the <jats:italic>SCN9A<\/jats:italic> gene, characterized by childhood onset of excruciating pain, redness, and warmth of acral sites. Patients often resort to ice water baths and other cooling measures to manage the discomfort. Hypothermia is a rare complication, reported only twice previously. We report a child with primary erythromelalgia due to a confirmed pathogenic variant admitted with life\u2010threatening hypothermia. Although the overuse of cooling mechanisms may have contributed, we postulate that the <jats:italic>SCN9A<\/jats:italic> mutation may lead to thermodysregulation and make patients with primary erythromelalgia particularly susceptible to this complication.<\/jats:p>","DOI":"10.1111\/pde.14866","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T06:56:54Z","timestamp":1639119414000},"page":"135-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Life\u2010threatening hypothermia in a child with primary erythromelalgia"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-6199","authenticated-orcid":false,"given":"Bayan","family":"Matarneh","sequence":"first","affiliation":[{"name":"Division of Pediatric Dermatology Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Witman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0347-1"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15327"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-990265"},{"key":"e_1_2_3_5_1","first-page":"2017","article-title":"Between fire and ice: refractory hypothermia and warmth\u2010induced pain in inherited erythromelalgia","author":"Tham SW","year":"2017","journal-title":"BMJ Case Rep"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.14866","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:52:21Z","timestamp":1693205541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.14866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,9]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/pde.14866"],"URL":"https:\/\/doi.org\/10.1111\/pde.14866","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2021,12,9]]},"assertion":[{"value":"2021-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}