{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:14:51Z","timestamp":1790615691044,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Capillary malformation\u2010arteriovenous malformation (CM\u2010AVM) syndrome is an autosomal dominant condition characterized by multifocal, noncontiguous pink patches on the skin that often have a surrounding pale halo. In some cases, an association with a fast flow, arteriovenous malformation (AVM) can be identified. Here, we describe a case report of a 16\u2010year\u2010old woman with CM\u2010AVM syndrome and significant cardiac compromise successfully treated with trametinib, a mitogen\u2010activated protein kinase (MEK) inhibitor.<\/jats:p>","DOI":"10.1111\/pde.14912","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T02:40:07Z","timestamp":1641868807000},"page":"316-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Successful management of an arteriovenous malformation with trametinib in a patient with capillary\u2010malformation arteriovenous malformation syndrome and cardiac compromise"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-093X","authenticated-orcid":false,"given":"Cynthia L.","family":"Nicholson","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Murati","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Boull","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"McGough","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology University of Minnesota  Minneapolis Minnesota 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