{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:05:52Z","timestamp":1791363952428,"version":"4.3.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Some full\u2010term newborns present with erythema and irritation of the buttocks and perianal area as early as the first 4\u00a0days of their lives. The effect of moisturizers in protecting this vulnerable skin has not been rigorously studied. This study aimed to clarify whether there is a difference in perianal skin barrier function with and without moisturizer application in the first month of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Comparative investigation of 118 full\u2010term newborns was performed, and they were allocated to intervention (<jats:italic>n<\/jats:italic>\u00a0=\u00a063) and control groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a055). The intervention group received moisturizer application to the perianal area, and the control group received care without application of moisturizer to the perianal area from the first day of life until the 1\u2010month visit. Transepidermal water loss (TEWL), stratum corneum hydration (SCH), and skin surface pH in the perianal area were measured as the indicators of skin barrier function on days 1 and 5 after birth and at the 1\u2010month visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 1\u2010month visit, TEWL was significantly decreased (intervention, 19.4\u00a0g\/m<jats:sup>2<\/jats:sup>\/h; control, 25.8\u00a0g\/m<jats:sup>2<\/jats:sup>\/h; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.00) and SCH was significantly increased (intervention, 58.8 arbitrary units (a.u.); control, 46.5 a.u.; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.00) in newborns using perianal moisturizer. The skin surface pH was not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of moisturizer was effective in protecting the skin barrier function of the perianal skin. Further investigations are needed to determine the effect on the frequency and extent of rashes in the perianal area.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.14962","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T13:43:34Z","timestamp":1649771014000},"page":"394-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of perianal skin barrier function with moisturizer application in Japanese full\u2010term newborns"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-842X","authenticated-orcid":false,"given":"Yuka","family":"Majima","sequence":"first","affiliation":[{"name":"Maternal Nursing and Midwifery Graduate Faculty of Interdisciplinary Research Graduate School University of Yamanashi  Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasue","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Maternal Nursing and Midwifery Graduate Faculty of Interdisciplinary Research Graduate School University of Yamanashi  Chuo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701239"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10659.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3418\/jjam.29.48"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12348"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2017.1363"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jspn.12022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12370"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.12047"},{"issue":"5","key":"e_1_2_8_10_1","first-page":"566","article-title":"A natural cream\u2010to\u2010powder formulation developed for the prevention of diaper dermatitis in diaper\u2010wearing infants and 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