{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:22:55Z","timestamp":1788790975353,"version":"build-2803163510"},"reference-count":84,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atopic dermatitis (AD) is a common disease with a broad spectrum of clinical manifestations. AD can manifest differently in adults than children. Core AD features are similar between children and adults overall, including lesions affecting flexural areas, presence of atopy, and xerosis. Adults have more signs of chronic disease, higher prevalence and different patterns of hand eczema, and a stronger relationship of disease activity with emotional factors, whereas children with AD have more exudative lesions, perifollicular accentuation, pityriasis alba, Dennie\u2013Morgan folds, and seborrheic dermatitis\u2010like presentation. These differences may be due in part to pathophysiologic differences in AD in children compared with adults. Atopic diseases commonly co\u2010occur with AD, although most do not temporally have the \u201catopic march.\u201d Further research is warranted to better understand the differential roles of immune dysregulation, epidermal\u2010barrier disruption, and dysbiosis between children and adults and determine whether such differences translate into differences in therapeutic efficacy.<\/jats:p>","DOI":"10.1111\/pde.14971","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T01:44:35Z","timestamp":1647481475000},"page":"345-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Differences between pediatric and adult atopic dermatitis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-8880","authenticated-orcid":false,"given":"Hassiel A.","family":"Ram\u00edrez\u2010Mar\u00edn","sequence":"first","affiliation":[{"name":"Department of Dermatology Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3686-7805","authenticated-orcid":false,"given":"Jonathan I.","family":"Silverberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology The George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2018.09.035"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3122\/JABFM.2019.02.180225"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190\u20109622(94)70004\u20104"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2018.05.1241"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2016.05.028"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12895\u2010020\u201000102\u20101"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2021.01.001"},{"issue":"2","key":"e_1_2_14_9_1","first-page":"138","article-title":"Leptin and atopic dermatitis in Korean elementary school children","volume":"15","author":"Seo S","year":"2016","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2018.02.040"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2008.07.027"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598\u2010020\u201059627\u20107"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/NG1767"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.14801"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/JCS.033969"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2009.07.034"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2012.07.008"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/S10038\u2010019\u20100628\u2010Y"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.13477"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2010.04.038"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2015.01.001"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2016.07.013"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMADERMATOL.2019.2983"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANAI.2017.10.037"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2017.05.034"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.12481"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2017.01.011"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1098\/RSPB.2014.3085"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.1196509"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/EJI.201141847"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201102400103"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1468\u20103083.2010.03794.X"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2015.05.049"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2015.12.1306"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2019.09.031"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2019.01.015"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAIP.2020.02.022"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/JCM4050979"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/GGI.12771"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2008.04.022"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2014.43"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2010.07.041"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE12655"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/JIMMUNOL.171.6.3262"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/JIMMUNOL.179.2.984"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2008.10.031"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.14888"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2016.04.053"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A015362"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/GM378"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1101\/GR.131029.111"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1034\/J.1398\u20109995.2000.00391.X"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(97)07302\u20109"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.312.7040.1195"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHPEDI.1966.02090120082007"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2018.11.006"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2015.10.049"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/J.1365\u20102222.1998.00439.X"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2009.11.026"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMADERMATOL.2013.10271"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PMED.1001748"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1542\/PEDS.2011\u20100204"},{"key":"e_1_2_14_64_1","first-page":"1","article-title":"Trends in allergic conditions among children: United States, 1997\u20102011","volume":"121","author":"Jackson KD","year":"2013","journal-title":"NCHS Data Brief"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2010.03.029"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/S12016\u2010018\u20108708\u2010X"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/CEA.12406"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NUTRES.2011.01.001"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0B013E328360949D"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANAI.2017.07.028"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.1953.x"},{"key":"e_1_2_14_72_1","unstructured":"NiggemannB SielaffB BeyerK BinderC WahnU.Outcome of double\u2010blind placebo\u2010controlled food challenge tests in 107 children with atopic dermatitis. Clinical and experimental allergy\u202f: journal of the British Society for Allergy and Clinical Immunol."},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200410000-00009"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000095"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.5662\/WJM.V5.I2.31"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAIP.2018.09.029"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000208"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2018.07.017"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2017.02.001"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/S40257\u2010017\u20100340\u20107"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190\u20109622(03)02539\u20108"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAIP.2012.09.002"},{"key":"e_1_2_14_83_1","unstructured":"XiaoA TsuchiyaA.Eczema Herpeticum. StatPearls Publishing;2021.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK560781\/Accessed December 17 2021"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANTIVIRAL.2013.02.010"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/BJD.20887"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.14971","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.14971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:51:56Z","timestamp":1692838316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.14971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,16]]},"references-count":84,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/pde.14971"],"URL":"https:\/\/doi.org\/10.1111\/pde.14971","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,16]]},"assertion":[{"value":"2022-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}