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While initial data from phase 2 trials in children less than 6\u2009years are promising, dupilumab use in children less than 6\u00a0months of age is not well studied. Here we present a case of a 5\u2010month\u2010old boy with severe primary AD, eosinophilia, hypogammaglobulinemia, and poor weight gain, who was successfully treated with dupilumab and experienced no serious adverse effects. To our knowledge, this is the youngest patient to receive dupilumab to date.<\/jats:p>","DOI":"10.1111\/pde.14980","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T02:07:14Z","timestamp":1650247634000},"page":"291-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety of dupilumab in a 5\u2010month\u2010old infant with severe atopic dermatitis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-748X","authenticated-orcid":false,"given":"Sonia A.","family":"Havele","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele C.","family":"Khurana","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Pediatrics The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Dermatology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"McMahon","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Pediatrics The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Dermatology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3995-7163","authenticated-orcid":false,"given":"Aditi S.","family":"Murthy","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Pediatrics The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Dermatology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania 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