{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:36:32Z","timestamp":1787168192313,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Hidradenitis suppurativa (HS) often develops in pediatrics, but few interventional studies include pediatric patients.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This dual analysis of a pediatric HS cohort and typical eligibility criteria in adult trials aims to identify potential patient characteristics and inclusion criteria for future pediatric HS studies.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This cross\u2010sectional and descriptive study is based on a prospectively collected data registry from an HS clinic. We also queried 125 HS studies from the\n Clinicaltrials.gov<\/jats:ext-link>\n database and information from 61 interventional systemic HS drug trials was analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The mean abscess and inflammatory nodule (AN) count in 81 pediatric subjects was 2.3 compared to 5.0 in adults with majority being Hurley stage I (39.5%, 32\/81) or II (55.6%, 45\/81). Most clinical trials required patients to be Hurley stage II\/III with AN count of \u22653.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n When developing clinical trials for pediatric HS, it is imperative to consider how baseline characteristics impact recruitment and disease assessment. Frequently used eligibility criteria in adult trials may severely limit pediatric recruitment. Although our registry had a large adult sample size, the main limitation of this study was the relatively smaller pediatric sample size.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pde.15026","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T09:10:26Z","timestamp":1656493826000},"page":"689-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A\n cross\u2010sectional<\/scp>\n study of pediatric hidradenitis suppurativa and the value of the International Hidradenitis Suppurativa Severity Score System (\n IHS4<\/scp>\n ) as a pediatric clinical trial inclusion criteria"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9058-8829","authenticated-orcid":false,"given":"Helen","family":"Bui","sequence":"first","affiliation":[{"name":"School of Medicine, University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-4637","authenticated-orcid":false,"given":"Christopher","family":"Sayed","sequence":"additional","affiliation":[{"name":"School of Medicine, University of North Carolina Chapel Hill North Carolina USA"},{"name":"Department of Dermatology, University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.02.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0201"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16101"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.04.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02053-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.12.007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.08.045"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-019-0363-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.3416"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4351"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.3227"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.11.017"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-014-0091-3"},{"issue":"5","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.jaad.2015.07.047","article-title":"New insights into the diagnosis of hidradenitis suppurativa: clinical presentations and phenotypes","volume":"73","author":"Zee HH","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15748"},{"key":"e_1_2_9_17_1","unstructured":"Medicine USNLo. 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Paper presented at: American Academy of Dermatology (AAD) 2021 VMX Event; April 23\u201325 2021.","DOI":"10.1016\/j.jaad.2021.06.140"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18983"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.10.044"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15939"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.15026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:36:35Z","timestamp":1692675395000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/pde.15026"],"URL":"https:\/\/doi.org\/10.1111\/pde.15026","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,29]]},"assertion":[{"value":"2021-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}