{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:08:39Z","timestamp":1791389319330,"version":"4.3.3"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hyper\u2010IgE syndromes (HIES) are a heterogeneous group of rare primary immunodeficiency diseases classically characterized by the triad of atopic dermatitis, and recurrent cutaneous and pulmonary infections. Autosomal dominant, loss\u2010of\u2010function\n                    <jats:italic>STAT3<\/jats:italic>\n                    pathogenic variants are the most common genetic cause, which lead to deficiency of Th17 lymphocytes, impaired interferon gamma production, and IL\u201010 signal transduction, and an unbalanced IL\u20104 state. Dupilumab, a monoclonal antibody to the IL\u20104a receptor, inhibits both IL\u20104 and IL\u201013, and has been shown to improve atopic dermatitis and other manifestations of HIES including asthma and allergic bronchopulmonary aspergillosis. We present a pediatric patient with HIES who presented predominantly with eosinophilic folliculitis, recurrent cutaneous infections, and other non\u2010eczematous findings and achieved sustained clearance with dupilumab.\n                  <\/jats:p>","DOI":"10.1111\/pde.15072","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T02:45:47Z","timestamp":1655952347000},"page":"940-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Clearance of atypical cutaneous manifestations of\n                    <scp>hyper\u2010IgE<\/scp>\n                    syndrome with dupilumab"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-2608","authenticated-orcid":false,"given":"Aman","family":"Nihal","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette R.","family":"Comstock","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen E.","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Division of Allergy, Immunology &amp; Rheumatology, Department of Pediatrics, School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Seroogy","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology &amp; Rheumatology, Department of Pediatrics, School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Arkin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.10.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12209"},{"key":"e_1_2_6_4_1","volume-title":"Job Syndrome","author":"Hafsi W","year":"2021"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06096"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa073687"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.09.009"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.02.025"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat4956"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3898"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161810"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.194233"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010020\u201000758\u2010x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.9.1119"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/302547"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105\u20102896.2005.00228.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20106749(86)90078\u20103"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2011.06387.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.01.011"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pde.15072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:29:09Z","timestamp":1692588549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,22]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/pde.15072"],"URL":"https:\/\/doi.org\/10.1111\/pde.15072","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,22]]},"assertion":[{"value":"2022-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}