{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:42:58Z","timestamp":1791664978247,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/objectives<\/jats:title><jats:p>We sought to describe the experience among members of the Hemangioma Investigator Group with pulsed dye laser (PDL) in the treatment of nonulcerated infantile hemangioma (IH) in pediatric patients in the pre\u2010 and post\u2010beta\u2010blocker era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter retrospective cohort study was conducted in patients with nonulcerated IH treated with laser therapy. Patient demographics, IH characteristics, indications for\/timing of laser therapy, as well as laser parameters were collected. Responses to laser therapy were evaluated using a visual analog scale (VAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and seventeen patients with IH were treated with PDL. 18\/117 (15.4%) had early intervention (defined as &lt;12\u2009months of life), and 99\/117 (84.6%) had late intervention (\u226512\u2009months of life). In the late intervention group, 73.7% (73\/99) had additional medical management of their IH. The mean age at PDL initiation for the late intervention group was 46.7\u2009\u00b1\u200935.3\u00a0months of life (range 12\u2013172\u2009months) with total number of treatments to maximal clearing of 4.2\u2009\u00b1\u20092.8 (range 1\u201317). Those who received propranolol prior to PDL received fewer sessions (1.1 fewer sessions, approaching significance [<jats:italic>p<\/jats:italic>\u00a0=\u00a0.056]). \u00a0 \u00a0 On the VAS, there was a mean 85% overall improvement compared to baseline (range 18%\u2013100%), with most improvement noted in erythema and\/or telangiectasias. The incidence of adverse effects was 6\/99 (6.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PDL is a useful tool in the treatment of IH, with notable improvement of telangiectasia and erythema and low risk of complications. \u00a0 PDL is often introduced after the maximal proliferative phase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.15132","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T04:49:36Z","timestamp":1663735776000},"page":"28-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Multicenter retrospective review of pulsed dye laser in nonulcerated infantile hemangioma"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0336-4278","authenticated-orcid":false,"given":"Sonal D.","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin F.","family":"Mathes","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-8439","authenticated-orcid":false,"given":"Eulalia","family":"Baselga","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona J.","family":"Frieden","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Powell","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics Sainte\u2010Justine University Hospital Center, University of Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Garzon","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pediatrics Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly D.","family":"Morel","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pediatrics Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-4831","authenticated-orcid":false,"given":"Christine T.","family":"Lauren","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pediatrics Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Dermatology Feinberg School of Medicine, Northwestern University and Ann and Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Chamlin","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Dermatology Feinberg School of Medicine, Northwestern University and Ann and Robert H. 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