{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T09:51:47Z","timestamp":1786960307773,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bachmann\u2013Bupp syndrome (OMIM #619075) is a novel autosomal dominant disorder caused by variants in the c\u2010terminus of the ornithine decarboxylase 1 gene, resulting in increased levels of ornithine decarboxylase. This case report includes two patients diagnosed with Bachmann\u2013Bupp syndrome who were treated with difluoromethylornithine through compassionate use approval from the United States Food and Drug Administration. In both patients, treatment with difluoromethylornithine has resulted in improved dermatologic signs, including regrowth of eyebrow and scalp hair and cessation of recurrent follicular cyst development.<\/jats:p>","DOI":"10.1111\/pde.15187","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T07:09:29Z","timestamp":1669705769000},"page":"528-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Improvement of dermatological symptoms in patients with <scp>Bachmann\u2013Bupp<\/scp> syndrome using difluoromethylornithine treatment"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-8225","authenticated-orcid":false,"given":"Antara","family":"Afrin","sequence":"first","affiliation":[{"name":"College of Human Medicine Michigan State University  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonia 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