{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:37:36Z","timestamp":1791398256371,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG034676"],"award-info":[{"award-number":["R01AG034676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Little is known about acne incidence in preadolescents and its potential association with body mass index (BMI). Our study aims to determine acne incidence in preadolescents and its association with BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based retrospective cohort study identified 7\u2010 to \u226412\u2009year\u2010olds with an initial acne diagnosis during 2010\u20132018, and incidence was calculated. Two age\u2010 and sex\u2010matched controls without acne were randomly selected per case, and BMI was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 643 acne patients were identified. Annual age\u2010 and sex\u2010adjusted incidence rate was 58.0 per 10,000 person\u2010years, higher in females vs. males (89.2 vs. 28.2 per 10,000 person\u2010years, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001), and increased with age (4.3, 24.4, and 144.3 per 10,000 person\u2010years among 7\u20138, 9\u201310, and 11\u201312\u2009year\u2010olds, respectively, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). Systemic medication use was associated with increasing BMI (odds ratio\u00a0=\u00a01.43 per 5\u00a0kg\/m<jats:sup>2<\/jats:sup> increase in BMI, 95% CI 1.07\u20131.92, <jats:italic>p<\/jats:italic>\u00a0=\u2009.015). Median BMI percentile was higher among acne cases vs. controls (75.0 vs. 65.0, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001), as was the proportion with BMI \u226595th percentile (16.7% vs. 12.2%, <jats:italic>p<\/jats:italic>\u00a0=\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acne incidence is higher in preadolescent girls than boys and increases with age. Preadolescents with acne are more likely to be obese than those without acne. Those with higher BMIs are more likely to be given systemic treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.15223","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T06:59:45Z","timestamp":1672815585000},"page":"428-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Acne incidence in preadolescents and association with increased body mass index: A population\u2010based retrospective cohort study of 643 cases with age\u2010 and sex\u2010matched community controls"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-6037","authenticated-orcid":false,"given":"Katinna E.","family":"Rodriguez Baisi","sequence":"first","affiliation":[{"name":"Ponce Health Sciences University  Ponce Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Biostatistics Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadir","family":"Shakshouk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha M.","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Pediatrics Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013\u20100490B"},{"key":"e_1_2_8_3_1","volume-title":"Prevalence of obesity among adults and youth: United States, 2015\u20132016","author":"Hales 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expression of insulin\u2010like growth factor\u20101?","volume":"36","author":"Seleit I","year":"2014","journal-title":"Anal Quant Cytopathol Histpathol"},{"issue":"3","key":"e_1_2_8_13_1","first-page":"251","article-title":"Higher body mass index is a significant risk factor for acne formation in schoolchildren","volume":"16","author":"Min\u2010Chien T","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.11.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq482"},{"issue":"246","key":"e_1_2_8_17_1","first-page":"1","article-title":"2000 CDC growth charts for the United States: methods and development","volume":"11","author":"Kuczmarski RJ","year":"2002","journal-title":"Vital Health 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