{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T10:29:50Z","timestamp":1769250590494,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pigmentary mosaicism (PM) is a descriptive term encompassing a range of hyper\u2010 and hypo\u2010pigmented phenotypes in various patterns. Information from the neurology literature initially noted neurological abnormalities (NA) in up to 90% of children with PM. The dermatology literature suggests lower associated rates (15%\u201330%) of NA. Variations in terminology, inclusion criteria, and small population sizes makes interpreting existing PM literature complicated. We aimed to assess rates of NA in children presenting to dermatology with PM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients &lt;19\u2009years, diagnosed with PM, nevus depigmentosus and\/or segmental caf\u00e9 au lait macules (CALM) seen in our dermatology department between 1 January 2006 and 31 December 2020. Patients with neurofibromatosis, McCune\u2010Albright syndrome, and non\u2010segmental CALM were excluded. Data collected included pigmentation, pattern, site(s) affected, presence of seizures, developmental delay, and microcephaly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fifty patients were included (49.3% female), with a mean age at diagnosis of 4.27\u2009years. Patterns of mosaicism were ascertained for 149 patients and included blaschkolinear (60\/149, 40.3%), blocklike (79\/149, 53.0%), or a combination of both patterns (10\/149, 6.7%). Patients with a combination of patterns were more likely to have NA (<jats:italic>p\u2009&lt;<\/jats:italic>\u00a0.01). Overall, 22\/149 (14.8%) had NA. Nine out of twenty\u2010two patients with NA had hypopigmented blaschkolinear lesions (40.9%). Patients with \u22654 body sites affected were more likely to have NA (<jats:italic>p\u2009&lt;<\/jats:italic>\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Overall, our population had low rates of NA in PM patients. A combination of blaschkolinear and blocklike patterns, or \u22654 body sites involved were associated with higher rates of NA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.15276","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T02:48:55Z","timestamp":1677120535000},"page":"446-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low rates of neurological abnormalities in patients with pigmentary mosaicism: A retrospective cohort study from a tertiary dermatology center"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-1928","authenticated-orcid":false,"given":"Kyla","family":"Pagani","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Massachusetts Chan Medical School  Worcester Massachusetts 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