{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:30:25Z","timestamp":1790631025877,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>Cutis marmorata telangiectatica congenita (CMTC) is a capillary malformation characterized by congenital, reticulated, well\u2010demarcated dark blue, red\u2010purple, or violaceous macules or plaques, with a coarse fixed livedo pattern. Nearly always, contiguous areas of skin atrophy and\/or ulceration are present. CMTC is usually localized but may rarely be generalized. Such generalized cases may be a feature of Adams\u2010Oliver syndrome (AOS). The nosologic confusion surrounding the term CMTC and uncertainty about the risk of associated abnormalities hinders the appropriate workup of patients and prognostic counseling for families. We hypothesized that the risk of associated anomalies in children with localized CMTC is very low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a literature review and retrospective review of patients with CMTC to propose a more precise clinical definition and ascertain the risk of associated anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 78 patients determined to have a diagnosis of CMTC based on consensus. The majority of patients had localized CMTC. Most patients with generalized CMTC met the criteria for the diagnosis of AOS. The associations found in patients with localized CMTC were mostly dermatological, with atrophy, ulcerations, or erosions present in 71%. Extracutaneous findings were present in 34.4% of patients and consisted mainly of extremity asymmetry (24.5%) that improved over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study showed a very low frequency of extracutaneous anomalies among patients with localized CTMC, ipsilateral limb discrepancy being the most common. We did not find a strong association with any other visceral anomalies that would justify routine evaluation in patients with localized CMTC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pde.15377","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T21:20:25Z","timestamp":1689283225000},"page":"820-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cutis marmorata telangiectatica congenita: Incidence of extracutaneous manifestations and a proposed clinical definition"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-1170","authenticated-orcid":false,"given":"Camila","family":"Downey","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Department of Dermatology, Hospital Luis Calvo Mackenna Facultad de Medicina Universidad de Chile  Santiago Chile"},{"name":"Department of Dermatology Cl\u00ednica Alemana de Santiago  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-1683","authenticated-orcid":false,"given":"Denise","family":"Metry","sequence":"additional","affiliation":[{"name":"Department of Dermatology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Garzon","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Pediatrics, Vagelos College of Physicians &amp; Surgeons Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Karem","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cl\u00ednica Marly JCG Ch\u00eda  Cundinamarca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-8439","authenticated-orcid":false,"given":"Eulalia","family":"Baselga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Department of Dermatology Hospital Sant Joan de Deu  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"202","article-title":"Uber eine seltene angeborene Hautanomalie (Cutis marmorata telangiectatica congenita)","volume":"3","author":"Van Lohuizen C","year":"1922","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12939"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.1.34"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u20101470.2000.01723.x"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"305","article-title":"Cutis marmorata telangiectatica congenita: report of nine cases and review of the literature","volume":"34","author":"Powell ST","year":"1984","journal-title":"Cutis"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31971"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2008.545"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2017.48"},{"key":"e_1_2_8_11_1","volume-title":"GeneReviews\u00ae","author":"Lehman A","year":"1993"},{"key":"e_1_2_8_12_1","unstructured":"ISSVA Classification of Vascular Anomalies \u00a92018 International Society for the Study of Vascular Anomalies. 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