{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:08:39Z","timestamp":1791389319348,"version":"4.3.3"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Treatment of severe eczema in patients with primary immunodeficiencies can be particularly challenging as there are no guidelines with regards to these conditions. Dupilumab is an interleukin (IL)\u20104R\u03b1 antagonist that inhibits both IL\u20104 and IL\u201013 and is approved for the treatment of atopic dermatitis in pediatric patients. In this report, we describe a patient with a case of severe eczema in the context of Wiskott\u2013Aldrich syndrome\u2010related disorder, who was successfully treated with dupilumab.<\/jats:p>","DOI":"10.1111\/pde.15397","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T01:41:57Z","timestamp":1689817317000},"page":"143-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Severe eczema in Wiskott\u2013Aldrich syndrome\u2010related disorder successfully treated with dupilumab"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-9879","authenticated-orcid":false,"given":"Fatmah","family":"Alzahrani","sequence":"first","affiliation":[{"name":"Division of Dermatology Phoenix Children's Hospital  Phoenix Arizona USA"},{"name":"Mayo Clinic College of Medicine and Science  Scottsdale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly K.","family":"Miller","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Phoenix Children's Hospital  Phoenix Arizona USA"},{"name":"The University of Arizona College of Medicine\u2010Phoenix  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Sacco","sequence":"additional","affiliation":[{"name":"The University of Arizona College of Medicine\u2010Phoenix  Phoenix Arizona USA"},{"name":"Division of Pulmonology, Section of Allergy\u2010Immunology Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Division of Dermatology Phoenix Children's Hospital  Phoenix Arizona USA"},{"name":"The University of Arizona College of Medicine\u2010Phoenix  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"issue":"6","key":"e_1_2_5_2_1","first-page":"1","article-title":"Dupilumab for moderate\u2010to\u2010severe atopic dermatitis","volume":"22","author":"Vangipuram R","year":"2017","journal-title":"Skin Ther Lett"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.022"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13951"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108452"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010022\u201001352\u2010z"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T09:12:49Z","timestamp":1706519569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,19]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/pde.15397"],"URL":"https:\/\/doi.org\/10.1111\/pde.15397","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,19]]},"assertion":[{"value":"2022-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}