{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:00:55Z","timestamp":1791896455169,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mucocutaneous eruptions are associated with numerous infectious processes and can present as erythema multiforme (EM), reactive infectious mucocutaneous eruption (RIME), Stevens Johnson syndrome (SJS), or toxic epidermal necrolysis (TEN). Limited reports have detailed the association of these eruptions with <jats:italic>SARS\u2010CoV\u20102<\/jats:italic> infection. We present a series of eight cases of severe mucocutaneous blistering eruptions associated with <jats:italic>SARS\u2010CoV\u20102<\/jats:italic> infection. A retrospective case series was performed at six tertiary medical centers from March 1, 2020 to August 1, 2022. Inclusion criteria were met with a clinical diagnosis of EM, RIME, SJS, or TEN and a positive <jats:italic>SARS\u2010CoV\u20102<\/jats:italic> test (rapid antigen or polymerase chain reaction) less than 4\u2009weeks prior to onset of dermatologic manifestation. Data was collected at time of each patient encounter. Eight patients met criteria with six pediatric patients (&lt;18\u2009years of age) having a median age of 15\u2009years and two adult patients (&gt;18\u2009years of age) having a median age of 36\u2009years. Patients were found to have a clinical diagnosis of RIME in 85.7% of cases. Oral mucosal involvement was the most common clinical finding (100%), followed by ocular (50.0%), urogenital (50.0%), and skin (37.5%) involvement. Evaluation did not reveal any additional infectious triggers in four patients. Evidence of possible concurrent or previous infectious triggers were identified in four patients. This case series highlights the development of severe mucocutaneous eruptions in association with <jats:italic>COVID\u201019<\/jats:italic> infection, as well as the potential contributing role of concurrent or prior infections.<\/jats:p>","DOI":"10.1111\/pde.15407","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T09:21:06Z","timestamp":1690881666000},"page":"990-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>COVID<\/scp>\u201019 associated severe mucocutaneous blistering eruptions: A case series"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3279-6939","authenticated-orcid":false,"given":"Allison E.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget E.","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Borghesi","sequence":"additional","affiliation":[{"name":"San Matteo Research Hospital  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Benincaso","sequence":"additional","affiliation":[{"name":"ASST Fatebenefratelli Sacco, Pediatric Unit  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bernardo","sequence":"additional","affiliation":[{"name":"ASST Fatebenefratelli Sacco, Pediatric Unit  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-3611","authenticated-orcid":false,"given":"Michele","family":"Ramien","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Department of Medicine University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-3413","authenticated-orcid":false,"given":"Irene","family":"Lara\u2010Corrales","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics Hospital for Sick Children, University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Yasmine","family":"Kirkorian","sequence":"additional","affiliation":[{"name":"Division of Dermatology Children's National Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0033-8285","authenticated-orcid":false,"given":"Sheilagh","family":"Maguiness","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Drolet","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.06.026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13140"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14419"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13921"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14780"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.1016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14801"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18213"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.10.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.0385"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15122"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14404"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14142"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102180\u20108\u201093"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20419.1"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T15:39:09Z","timestamp":1704209949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/pde.15407"],"URL":"https:\/\/doi.org\/10.1111\/pde.15407","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}