{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:17:38Z","timestamp":1790014658243,"version":"4.0.1"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Port wine birthmarks (PWB) are capillary vascular malformations within the papillary and reticular dermis, most commonly occurring on the head and neck and may darken and thicken with age. Pulsed dye laser (PDL) is the gold standard of treatment for PWB as it selectively targets involved vessels. Sirolimus is a macrolide antibiotic that selectively inhibits mammalian target of rapamycin, thereby suppressing the angiogenesis pathways that can be activated by PDL. Sirolimus and PDL may be used together to treat PWB. We present a case series describing three cases of delayed ulceration and systemic sirolimus absorption following combination therapy, highlighting a potential complication and patient safety concern.<\/jats:p>","DOI":"10.1111\/pde.15409","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T07:19:57Z","timestamp":1691824797000},"page":"108-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Delayed ulceration following combination pulse dye laser and topical sirolimus treatment for port wine birthmarks: A case series"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0893-8111","authenticated-orcid":false,"given":"Catherine Grace P.","family":"Hobayan","sequence":"first","affiliation":[{"name":"College of Medicine, The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Nourse","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela M.","family":"Paradiso","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-6730","authenticated-orcid":false,"given":"Esteban","family":"Fernandez Faith","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology Nationwide Children's Hospital and College of Medicine, The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22436"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22548"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22101"},{"key":"e_1_2_5_5_1","article-title":"Treatment of port wine stain with Tixel\u2010induced rapamycin delivery following pulsed dye laser application","volume":"33","author":"Artzi O","year":"2019","journal-title":"Dermatol Ther"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13867"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2018.376"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.10.011"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1306018"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T14:13:18Z","timestamp":1706537598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,12]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/pde.15409"],"URL":"https:\/\/doi.org\/10.1111\/pde.15409","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,12]]},"assertion":[{"value":"2023-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}