{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:46Z","timestamp":1747187506706,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leukocyte adhesion deficiency (LAD), a disorder of neutrophil function, is characterized by a defect in leukocyte adhesion to the endothelium. Recurrent infections in the skin, soft tissue, gingiva, and lungs due to <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, and <jats:italic>Klebsiella<\/jats:italic> sp. are common in these patients. Ecthyma gangrenosum (EG) is an ulcer of skin and subcutaneous tissue with a black eschar and surrounding erythematous halo secondary to a bacterial infection. Here, we report an unusual presentation of LAD type\u20101 with extensive EG of perineum secondary to <jats:italic>Staphylococcus hominis<\/jats:italic> bacteremia treated successfully with combination of granulocyte transfusion and diversion colostomy.<\/jats:p>","DOI":"10.1111\/pde.15492","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:20:36Z","timestamp":1703722836000},"page":"501-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extensive perineal ecthyma gangrenosum in leukocyte adhesion deficiency type 1 associated with <i>Staphylococcus hominis<\/i> bacteremia"],"prefix":"10.1111","volume":"41","author":[{"given":"Balamurugan","family":"Kalyanaprabhakaran","sequence":"first","affiliation":[{"name":"Department of Pediatrics Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkataraman Ranjith","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaikumar Govindaswamy","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-3342","authenticated-orcid":false,"given":"Pediredla","family":"Karunakar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhandapany","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibekanand","family":"Jindal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.12.008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2277-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70210-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.9.4877-4879.2005"},{"issue":"3","key":"e_1_2_5_6_1","first-page":"420","article-title":"Staphylococcus hominis subsp. novobiosepticus, an emerging multidrug\u2010resistant bacterium, as a causative agent of septicaemia in cancer patients","volume":"146","author":"Ahmed NH","year":"2017","journal-title":"Indian J Med Res"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237111"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-10-10"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.02.026"},{"issue":"6","key":"e_1_2_5_10_1","first-page":"429","article-title":"Ecthyma gangrenosum as an initial manifestation of acute lymphoblastic leukemia","volume":"97","author":"Gebell\u00ed Jov\u00e9 P","year":"2022","journal-title":"An Pediatr (Engl Ed)"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001028"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.4.1629.bloodjournal8641629"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T15:30:24Z","timestamp":1715700624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,27]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/pde.15492"],"URL":"https:\/\/doi.org\/10.1111\/pde.15492","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2023,12,27]]},"assertion":[{"value":"2023-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}