{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:55:16Z","timestamp":1790286916778,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous adverse events are commonly reported in adult patients with chronic myeloid leukemia (CML) receiving tyrosine kinase inhibitors (TKIs); however, little is known about the cutaneous reactions in children receiving TKIs for CML. As pediatric patients may require lifelong TKI therapy, it is essential to understand the wide range of potential cutaneous toxicities. We examined all case studies, cohort studies, and clinical trials in PubMed\/MEDLINE and Embase that reported cutaneous reactions to first\u2010, second\u2010, and third\u2010generation TKIs in children 18\u2009years or younger with CML. This review article focuses on the TKI drug types and doses, patient demographic characteristics, features of skin reactions, and clinical outcomes.<\/jats:p>","DOI":"10.1111\/pde.15505","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:19:51Z","timestamp":1703722791000},"page":"169-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Skin reactions to tyrosine kinase inhibitors in pediatric patients with chronic myeloid leukemia"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-9033","authenticated-orcid":false,"given":"Michelle","family":"Toker","sequence":"first","affiliation":[{"name":"Division of Dermatology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Jaller","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Delbourgo Patton","sequence":"additional","affiliation":[{"name":"D. 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