{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:41:10Z","timestamp":1770961270552,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ichthyoses are a heterogeneous group of skin disorders characterized by scaling and erythema. Recognizing the variability of scale and erythema by region and ichthyosis subtype, we developed the Ichthyosis Scoring System (ISS) to quantify severity. We previously found ISS to have high inter\u2010 and intrarater reliability in evaluating photographic images. To confirm ISS clinical utility, we examined its performance at the 2022 Foundation for Ichthyosis and Related Skin Types conference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010five participants were evaluated by 3 of 9 medical professionals trained to score ichthyosis scale and erythema using ISS. Intrarater and interrater intraclass correlation coefficients (ICC) were analyzed using one\u2010way and two\u2010way random effects models, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intrarater reliability was excellent (ICC\u2009=\u20090.931, 95% CI, 0.921\u20130.940) for scale and good (ICC\u2009=\u20090.876, 95% CI, 0.853\u20130.899) for erythema scoring. Compared to photo validation with excellent intrarater reliability ratings for both scale (ICC\u2009=\u20090.956, 95% CI, 0.925\u20130.974) and erythema (ICC\u2009=\u20090.913, 95% CI, 0.855\u20130.949), ISS demonstrated equivalent reliability for live use. Overall interrater reliability for 10 body sites showed excellent (ICC &gt;0.9) and good (ICC &gt;0.75) agreement and consistency for both scale and erythema. Palms were an exception, demonstrating moderate (ICC &gt;0.5) interrater agreement and consistency for erythema evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ISS is a reliable measure of global and regional ichthyosis severity during in\u2010person evaluations. Ease\u2010of\u2010use, accessibility, and content validity in both live and photographic evaluation endorse ISS as a standard for ichthyosis severity analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.15508","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T05:44:06Z","timestamp":1705556646000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In\u2010person validation of the Ichthyosis Scoring System"],"prefix":"10.1111","volume":"41","author":[{"given":"Caroline","family":"Echeandia\u2010Francis","sequence":"first","affiliation":[{"name":"Department of Dermatology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qisi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Asch","sequence":"additional","affiliation":[{"name":"Hometown Pediatric Dermatology  North Oaks Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Bayart","sequence":"additional","affiliation":[{"name":"Division of Dermatology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latanya","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Florida Atlantic University  Coral Springs Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-1458","authenticated-orcid":false,"given":"Sarah D.","family":"Cipriano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-7691","authenticated-orcid":false,"given":"Brittany","family":"Craiglow","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-8960","authenticated-orcid":false,"given":"Jonathan","family":"Dyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Missouri School of Medicine  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moise L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Texas at Austin Dell School of Medicine  Austin Texas USA"},{"name":"Department of Pediatrics The University of Texas at Austin Dell School of Medicine  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Lilly","sequence":"additional","affiliation":[{"name":"Department of Dermatology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Newell","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Missouri\u2010Kansas City School of Medicine  Kansas City Missouri USA"},{"name":"Department of Internal Medicine University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingchen","family":"Liang","sequence":"additional","affiliation":[{"name":"Yale Center Analytical Sciences, Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geliang","family":"Gan","sequence":"additional","affiliation":[{"name":"Yale Center Analytical Sciences, Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Deng","sequence":"additional","affiliation":[{"name":"Yale Center Analytical Sciences, Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy S.","family":"Paller","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith A.","family":"Choate","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Genetics Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Pathology Yale University School of Medicine  New Haven Connecticut 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