{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T04:54:00Z","timestamp":1786510440047,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Current regulatory labeling recommends avoiding live vaccine use in dupilumab\u2010treated patients. Clinical data are not available to support more specific guidance for live or live attenuated vaccines administration in dupilumab\u2010treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children (6 months\u20135\u2009years old) with moderate\u2010to\u2010severe atopic dermatitis (AD) enrolled in a phase 2\/3 clinical trial of dupilumab (LIBERTY AD PRESCHOOL Part A\/B; NCT03346434) and subsequently participated in the LIBERTY AD PED\u2010OLE (NCT02612454). During these studies, protocol deviations occurred in nine children who received measles, mumps, rubella (MMR) vaccine with or without varicella vaccine; five with a \u226412\u2010week gap between dupilumab administration and vaccination and four with a &gt;12\u2010week gap after discontinuing dupilumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine children (1 female; 8 male) had severe AD at baseline (8\u201356 months old). Of the nine children, five had a \u226412\u2010week gap ranged 1\u20137\u2009weeks between dupilumab administration and vaccination who received MMR vaccine (<jats:italic>n<\/jats:italic>\u2009=\u20092) or MMR and varicella vaccines (<jats:italic>n<\/jats:italic>\u2009=\u20093); among these, one resumed dupilumab treatment as early as 2\u2009days and four resumed treatment 18\u201343\u2009days after vaccination. No treatment\u2010emergent adverse events, including serious adverse events and infections, were reported within the 4\u2010week post\u2010vaccination period in any children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this case series of dupilumab\u2010treated children with severe AD who received MMR vaccine with or without varicella vaccine, no adverse effects (including vaccine\u2010related infection) were reported within 4\u2009weeks after vaccination. Further studies are warranted to evaluate the safety, tolerability, and immune response to live attenuated vaccines in dupilumab\u2010treated patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.15518","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T06:34:52Z","timestamp":1706942092000},"page":"204-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A case series of live attenuated vaccine administration in dupilumab\u2010treated children with atopic dermatitis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-9905","authenticated-orcid":false,"given":"Elaine C.","family":"Siegfried","sequence":"first","affiliation":[{"name":"Department of Dermatology and Pediatrics Saint Louis University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Pediatric Dermatology Cardinal Glennon Children's Hospital  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Wine Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Spergel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Allergy and Immunology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Prescilla","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet","family":"Uppal","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Coleman","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Bansal","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-0054","authenticated-orcid":false,"given":"Sonya L.","family":"Cyr","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-8164","authenticated-orcid":false,"given":"Brad","family":"Shumel","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"DUPIXENT\u00ae (dupilumab). Highlights of prescribing information. Accessed November 2 2023.https:\/\/www.regeneron.com\/downloads\/dupixent_fpi.pdf"},{"key":"e_1_2_9_3_1","unstructured":"DUPIXENT\u00ae (dupilumab). Summary of product characteristics. Accessed November 2 2023.https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/dupixent-epar-product-information_en.pdf"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16928"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01539\u20102"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010022\u201000683\u20102"},{"key":"e_1_2_9_7_1","unstructured":"National Library of Medicine.MedlinePlus: Vaccines \u2013 immunizations. Accessed November 2 2023.https:\/\/medlineplus.gov\/ency\/article\/002024.htm"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1298443"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.048"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2021.12.003"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T14:21:34Z","timestamp":1738333294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/pde.15518"],"URL":"https:\/\/doi.org\/10.1111\/pde.15518","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"2023-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}