{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:07:08Z","timestamp":1792084028653,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR071491"],"award-info":[{"award-number":["R01AR071491"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We present the case of a 20\u2010month\u2010old girl with Schimmelpenning\u2010Feuerstein\u2010Mims (SFM) syndrome with extensive head, neck, and torso skin involvement successfully managed with topical trametinib. Trametinib interferes downstream of\n                    <jats:italic>KRAS<\/jats:italic>\n                    and\n                    <jats:italic>HRAS<\/jats:italic>\n                    in the MAPK signaling pathway, of which\n                    <jats:italic>KRAS<\/jats:italic>\n                    was implicated in our child's pathogenic variant. Although other dermatologic conditions have shown benefit from oral trametinib, its topical use has not been well reported. Our patient showed benefit from the use of twice\u2010daily topical trametinib, applied to the epidermal and sebaceous nevi over a 16\u2010month period, leading to decreased pruritus and thinning of the plaques.\n                  <\/jats:p>","DOI":"10.1111\/pde.15523","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T02:54:15Z","timestamp":1706237655000},"page":"523-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Topical trametinib for epidermal and sebaceous nevi in a child with\n                    <scp>Schimmelpenning\u2010Feuerstein\u2010Mims<\/scp>\n                    syndrome"],"prefix":"10.1111","volume":"41","author":[{"given":"Courtney N.","family":"Haller","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology, Dell Medical School University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4965-0050","authenticated-orcid":false,"given":"Maria A.","family":"Leszczynska","sequence":"additional","affiliation":[{"name":"Department of Dermatology Baylor Scott and White  Temple Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9103-609X","authenticated-orcid":false,"given":"Lars","family":"Brichta","sequence":"additional","affiliation":[{"name":"Chemistry Rx Compounding and Specialty Pharmacy  Folcroft Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Maier","sequence":"additional","affiliation":[{"name":"Drug Dynamics Institute, College of Pharmacy The University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Riddington","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Choate","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Pathology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Genetics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moise L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology, Dell Medical School University of Texas  Austin Texas USA"},{"name":"Department of Pediatrics, Division of Pediatric Dermatology, Dell Medical School University of Texas  Austin Texas USA"},{"name":"Dell Children's Medical Center  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"HappleR.Epidermal Nevus Syndromes. NORD Rare Disease Database.2011Accessed September 4 2022.https:\/\/Rarediseases.Org\/Rare-Diseases\/Epidermal-Nevus-Syndromes\/"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-2993-y"},{"key":"e_1_2_6_4_1","first-page":"97","volume-title":"Handbook of Clinical Neurology","author":"Asch S","year":"2015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.11.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.38363"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0096-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13038"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-2469"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.4653"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13731"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803508-5.00020-2"},{"key":"e_1_2_6_13_1","first-page":"2251","article-title":"Trametinib: a MEK inhibitor for management of metastatic melanoma","volume":"8","author":"Lugowska I","year":"2015","journal-title":"OncoTargets Ther"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T11:32:05Z","timestamp":1715686325000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/pde.15523"],"URL":"https:\/\/doi.org\/10.1111\/pde.15523","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]},"assertion":[{"value":"2023-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}