{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:19:28Z","timestamp":1782782368643,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite studies of dermatologic manifestations in adults with inflammatory bowel disease (IBD), little is known about the prevalence of IBD\u2010associated skin lesions and their correlation with IBD severity in children. We aimed to address these knowledge gaps in our single\u2010center cohort of children with IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review of 528 children and adolescents (\u226418\u2009years old) with IBD and seen at Mayo Clinic (Rochester, MN) between 1999 and 2017 was conducted. The Chi\u2010Square\/Fischer's exact test (with <jats:italic>p<\/jats:italic>\u2009\u2264\u2009.05 to signify statistical significance) was applied to compare categorical outcomes between Crohn's disease (CD) and ulcerative colitis (UC) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 425 IBD patients (64.9% CD, 53% males) and \u22651 dermatologic diagnosis were included. Presence of \u22651 cutaneous infection was recorded in 42.8% of participants. Acne was the most common non\u2010infectious dermatologic condition (30.8%), followed by eczema (15.8%) and perianal skin tags (14.6%). Angular cheilitis (<jats:italic>p<\/jats:italic>\u2009=\u2009.024), keratosis pilaris (KP, <jats:italic>p<\/jats:italic>\u2009=\u2009.003), and perianal skin complications (i.e., skin tags, fistula, and abscesses; all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) were more frequently diagnosed among children with CD, while fungal skin infections (<jats:italic>p<\/jats:italic>\u2009=\u2009.017) were more frequently diagnosed in UC patients. Severity of IBD correlated with higher prevalence of perianal fistula (<jats:italic>p<\/jats:italic>\u2009=\u2009.003), perianal abscess (<jats:italic>p<\/jats:italic>\u2009=\u2009.041), psoriasis (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and pyoderma gangrenosum (PG, <jats:italic>p<\/jats:italic>\u2009=\u2009.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both IBD\u2010specific and IBD\u2010nonspecific dermatologic conditions are very prevalent in childhood IBD, the most common being infectious. Children with CD are more likely to experience angular cheilitis, KP, and perianal skin findings than those with UC. Perianal disease, psoriasis, and PG\u00a0are associated with more severe IBD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.15538","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T02:58:27Z","timestamp":1707361107000},"page":"234-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dermatologic manifestations in pediatric patients with inflammatory bowel disease"],"prefix":"10.1111","volume":"41","author":[{"given":"Mohsen","family":"Afarideh","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Bartoletta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha M.","family":"Tollefson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Pediatrics and Adolescent Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2251-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2019.01.06"},{"issue":"4","key":"e_1_2_9_4_1","first-page":"235","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"7","author":"Levine JS","year":"2011","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56090425"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8617-4"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"21","article-title":"Management of cutaneous disorders related to inflammatory bowel disease","volume":"25","author":"Pellicer Z","year":"2012","journal-title":"Ann Gastroenterol"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"158","article-title":"Cutaneous manifestations of inflammatory bowel disease","volume":"1","author":"Georgiou S","year":"2006","journal-title":"Hosp Chron"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020364"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.01.009"},{"key":"e_1_2_9_11_1","unstructured":"UpToDate.Comparison of representative topical corticosteroid preparations (classified according to the United States system). 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