{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:32:18Z","timestamp":1777480338736,"version":"3.51.4"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaplastic lymphoma kinase (ALK)\u2010positive histiocytosis is a rare disease that usually occurs in infants and young children and is characterized by ALK\u2010positive histiocytes infiltrating organs. We present a case of multisystem involvement of ALK\u2010positive histiocytosis in a female infant with skin nodules as the initial presentation. Despite multiorgan involvement, most tumors had spontaneously regressed, and all bones were partially healed after 40\u2009months of regular follow\u2010up without treatment. However, gait abnormalities persisted, indicating that early treatment may have greater impact in maintaining a child's quality of life when the disease involves the brain or the critical period of bone development.<\/jats:p>","DOI":"10.1111\/pde.15546","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T19:31:16Z","timestamp":1707766276000},"page":"551-553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anaplastic lymphoma kinase\u2010positive histiocytosis with multisystem involvement: A case report"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4673-1653","authenticated-orcid":false,"given":"Yaojun","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7396-2943","authenticated-orcid":false,"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chengdu Women's and Children's Central Hospital, School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013338"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001613\u20101"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010018\u20100168\u20106"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508524"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010023\u201002649\u2010x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T15:30:43Z","timestamp":1715700643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/pde.15546"],"URL":"https:\/\/doi.org\/10.1111\/pde.15546","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,12]]},"assertion":[{"value":"2023-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}