{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:51:40Z","timestamp":1777542700231,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Idiopathic aseptic facial granuloma (IAFG) is an underrecognized pediatric skin disease, currently considered within the spectrum of rosacea. It usually manifests as a solitary, reddish, asymptomatic nodule on the cheek that resolves spontaneously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective and descriptive observational study of 43 pediatric patients with a clinical diagnosis of IAFG, followed between 2004 and 2022, at two general hospitals in Argentina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IAFG predominated in girls (65%) and the average age of onset was about 6\u2009years. A single asymptomatic nodule was seen in 79% of patients. The most common localization was the cheek (58%) followed by lower eyelids (41%). Family history of rosacea was present in 16% of patients. A concomitant diagnosis of rosacea and periorificial dermatitis was made in 14% and 9% of our population, respectively. Past or present history of chalazia was detected in 42% of the children. IAFG diagnosis was mainly clinical (88% of cases). Oral antibiotics were the most common indicated treatment (84%). Complete healing was achieved by the majority, but 18% of those with eyelid compromise healed with scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IAFG is a benign pediatric condition that physicians should recognize in order to manage correctly. We herein refer to a particular morphologic aspect of IAFG lesions affecting the lower eyelids, where nodules adopt a linear distribution and have a higher probability of involute leaving a scar. Also, we consider that the concomitant findings of rosacea, periorificial dermatitis and chalazia in our patients, reinforce the consideration of IAFG within the spectrum of rosacea.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pde.15571","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:59:35Z","timestamp":1709081975000},"page":"243-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Idiopathic aseptic facial granuloma: A retrospective study of 43 cases"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8824-0302","authenticated-orcid":false,"given":"Lola","family":"Kuperman Wilder","sequence":"first","affiliation":[{"name":"Pediatric Dermatology Section, Dermatology Department Hospital Ramos Mej\u00eda  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonela","family":"Lamberti","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Section, Dermatology Department Hospital Ramos Mej\u00eda  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Boggio","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Section, Dermatology Department Hospital Ramos Mej\u00eda  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"Abad","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Section, Dermatology Department Hospital Ramos Mej\u00eda  Buenos Aires Argentina"},{"name":"Dermatology Department Hospital Alem\u00e1n  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula C.","family":"Luna","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Alem\u00e1n  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Larralde","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Section, Dermatology Department Hospital Ramos Mej\u00eda  Buenos Aires Argentina"},{"name":"Dermatology Department Hospital Alem\u00e1n  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"issue":"9","key":"e_1_2_7_2_1","first-page":"1253","article-title":"Idiopathic aseptic facial granuloma (pyodermite froide du visage): a pediatric entity?","volume":"137","author":"Roul S","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2019.01.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01689.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13161"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16142471"},{"issue":"3","key":"e_1_2_7_7_1","first-page":"266","article-title":"Idiopathic facial aseptic granuloma: usefulness of cutaneous ultrasound","volume":"108","author":"V\u00e1zquez\u2010Osorio I","year":"2017","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13492"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13324"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07741.x"},{"issue":"1","key":"e_1_2_7_11_1","first-page":"56","article-title":"Idiopathic facial aseptic granuloma: a case report","volume":"117","author":"Garais JA","year":"2019","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12137"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13257"},{"issue":"5","key":"e_1_2_7_14_1","first-page":"451","article-title":"Lower eyelid nodule: chalazion or idiopathic facial aseptic granuloma? A case series","volume":"101","author":"Zanella A","year":"2021","journal-title":"Acta Derm Venereol"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T14:20:51Z","timestamp":1738333251000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/pde.15571"],"URL":"https:\/\/doi.org\/10.1111\/pde.15571","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,27]]},"assertion":[{"value":"2023-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}