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A comprehensive search was conducted for publications evaluating BMT and bone marrow\u2010derived mesenchymal stem cell (BM\u2010MSC) therapy for EB in PubMed\/MEDLINE, Google Scholar, and Cochrane databases from inception until June 2023. A total of 55 participants with severe forms of EB had BMT and\/or BM\u2010MSCs, with recessive dystrophic EB as the most common EB type; 53 (96.4%) patients had better wound healing, and 3 (5.5%) patients died of sepsis. The most common adverse events reported were graft failure, sepsis, graft\u2010versus\u2010host disease, and renal insufficiency. Allogeneic BMT is a high\u2010risk procedure with possible benefits and adverse events. BM\u2010MSCs revealed favorable outcomes to improve the safety of EB cell\u2010based therapy by minimizing the risk of serious adverse events, reducing blisters, and accelerating wound healing. Further studies are needed to assess the treatment's long\u2010term effects and clarify the risk\/benefit ratio of procedure versus conventional therapy.<\/jats:p>","DOI":"10.1111\/pde.15591","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T07:14:20Z","timestamp":1711955660000},"page":"599-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bone marrow transplantation and bone marrow\u2010derived mesenchymal stem cell therapy in epidermolysis bullosa: A systematic review"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6046-9458","authenticated-orcid":false,"given":"Maulidina","family":"Agustin","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada  Yogyakarta 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