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The lesion was initially diagnosed as a giant congenital melanocytic nevus based on clinical exam and histopathology with immunohistochemical stains. The patient was later diagnosed with neurofibromatosis type 1, and the lesion on the back developed a \u201cbag of worms\u201d texture consistent with a plexiform neurofibroma and found to harbor a pathogenic variant in the <jats:italic>NF1<\/jats:italic> gene. This case highlights the diagnostic challenge of differentiating these lesions and their overlapping clinical and histopathological features.<\/jats:p>","DOI":"10.1111\/pde.15611","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T03:04:30Z","timestamp":1712027070000},"page":"878-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plexiform neurofibroma masquerading as a giant congenital melanocytic nevus"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4843-6042","authenticated-orcid":false,"given":"Gerilyn M.","family":"Olsen","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn H.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Pediatrics Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8060-4311","authenticated-orcid":false,"given":"Olayemi","family":"Sokumbi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Laboratory Medicine &amp; Pathology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-2718","authenticated-orcid":false,"given":"Yvonne E.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Dermatology (Division of Pediatric Dermatology) and Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118441213.rtd0076"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2015.06.001a"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019605\u2010200507000\u201000012"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190\u20109622(08)80723\u20102"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200003000\u201000001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.05.018"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31828950a3"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T12:13:39Z","timestamp":1737116019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/pde.15611"],"URL":"https:\/\/doi.org\/10.1111\/pde.15611","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}