{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:17:48Z","timestamp":1789521468283,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>PLACK syndrome (OMIM 616295) is a rare genodermatosis associated with peeling skin, leukonychia, acral punctate keratosis, cheilitis, and knuckle pads and is caused by loss\u2010of\u2010function mutations in the <jats:italic>CAST<\/jats:italic> gene, which encodes calpastatin, a calcium\u2010dependent protease. This case report highlights a case of PLACK syndrome presenting with the unique findings of striate hyperkeratosis on the palms as well as life\u2010threatening cardiomyopathy. We review why <jats:italic>CAST<\/jats:italic> mutations might impact cardiac function and raise awareness of the potential association between PLACK syndrome and cardiac manifestations.<\/jats:p>","DOI":"10.1111\/pde.15671","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T12:35:56Z","timestamp":1720787756000},"page":"1211-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CASTing the net wider: A case report of PLACK syndrome associated with dilated cardiomyopathy"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8426-2627","authenticated-orcid":false,"given":"Cassidy","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology Dell Medical School, University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology Dell Medical School, University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Little","sequence":"additional","affiliation":[{"name":"Dell Medical School, University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Carruth","sequence":"additional","affiliation":[{"name":"Dell Medical School, University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nolan","sequence":"additional","affiliation":[{"name":"Dell Medical School, University of Texas  Austin Texas USA"},{"name":"Department of Pediatrics, Division of Clinical Genetics Dell Medical School, University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ruth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Dermatology Dell Medical School, University of Texas  Austin Texas USA"},{"name":"Dell Medical School, University of Texas  Austin Texas USA"},{"name":"Division of Pediatric Dermatology Dell Children's Medical Center  Austin Texas USA"},{"name":"Department of Pediatrics, Division of Pediatric Dermatology Dell Medical School, University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14383"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.05.013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2019.12.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.108"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16760"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad185"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.11.013"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10082024"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000261938.28365.11"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.567206"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-019-03077-9"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:55:53Z","timestamp":1732092953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,12]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/pde.15671"],"URL":"https:\/\/doi.org\/10.1111\/pde.15671","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,12]]},"assertion":[{"value":"2024-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}