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Numerical thresholds of significance have been described in the dermatologic literature for various skin findings where the likelihood of an associated extracutaneous abnormality or known genetic syndrome increases significantly. Knowledge of these numerical thresholds facilitates diagnosis and management, which improves clinical outcomes and avoids severe complications. This review highlights the clinical presentation, complications, evaluation, and numerical significance, when applicable, for the following skin findings: infantile hemangiomas, capillary malformations, caf\u00e9\u2010au\u2010lait macules, hypopigmented macules, juvenile xanthogranulomas, pilomatricomas, and angiofibromas.<\/jats:p>","DOI":"10.1111\/pde.15687","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T11:56:00Z","timestamp":1725537360000},"page":"1021-1029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How many is too many? 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