{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:12:30Z","timestamp":1791389550932,"version":"4.3.3"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Our study aims to synthesize existing evidence of dupilumab for alopecia areata (AA) in pediatric patients with atopic dermatitis (AD). We searched MEDLINE and Embase on March 1, 2024, using keywords related to AD, AA, dupilumab, and pediatric patient populations per PRISMA\u2010ScR guidelines. A mean SALT score reduction of 42.6 following dupilumab treatment (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01) over an average of 3.21\u2009months, and a mean reduction of Investigator Global Assessment (IGA) levels of 2.14\u2009units (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01) demonstrates the efficacy of dupilumab in pediatric AA when there is concurrent AD. Our findings in combination with dupilumab's favorable safety profile in pediatric AD makes it an appealing option for AA treatment, however, a greater understanding of the underlying mechanisms, optimal pediatric patient selection criteria, long\u2010term efficacy, and safety profile of dupilumab in this context is warranted.\n                  <\/jats:p>","DOI":"10.1111\/pde.15691","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T03:34:53Z","timestamp":1720064093000},"page":"1123-1126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dupilumab for the treatment of alopecia areata in pediatric patients with atopic dermatitis: A scoping review"],"prefix":"10.1111","volume":"41","author":[{"given":"Dea","family":"Metko","sequence":"first","affiliation":[{"name":"Michael G. DeGroote School of Medicine McMaster University  Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2771-266X","authenticated-orcid":false,"given":"Shanti","family":"Mehta","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-1121","authenticated-orcid":false,"given":"Cathryn","family":"Sibbald","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dermatology The Hospital for Sick Children, University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2976"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.936488"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15071"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406223231191049"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.07.015"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.10.010"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2024.2312245"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.01.046"},{"issue":"12","key":"e_1_2_4_10_1","first-page":"3397","article-title":"The role of serum Th1, Th2, and Th17 cytokines in patients with alopecia Areata: clinical implications","volume":"10","author":"Wa\u015bkiel\u2010Burnat A","year":"2021","journal-title":"Cells (Basel, Switzerland)"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T03:54:35Z","timestamp":1732074875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/pde.15691"],"URL":"https:\/\/doi.org\/10.1111\/pde.15691","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,4]]},"assertion":[{"value":"2024-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}