{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:08:20Z","timestamp":1749182900590,"version":"3.41.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent infections with <jats:italic>Candida<\/jats:italic> spp., often linked to primary immunodeficiencies. We report a case of two 8\u2010year\u2010old monozygotic twin brothers presenting with extensive dermatophytosis, later diagnosed with autoimmune polyendocrinopathy, candidiasis, and ectodermal dystrophy (APECED) syndrome due to a homozygous p.M1V mutation in the <jats:italic>AIRE<\/jats:italic> gene. The twins exhibited widespread skin and nail infection, along with malabsorption, dental caries, and other autoimmune manifestations. This case highlights the novel presentation of extensive dermatophytosis in APECED, underscoring the variability in clinical expression even within a single family.<\/jats:p>","DOI":"10.1111\/pde.15736","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T03:14:02Z","timestamp":1726024442000},"page":"145-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recalcitrant extensive dermatophytosis in twin brothers with <scp>APECED<\/scp> syndrome"],"prefix":"10.1111","volume":"42","author":[{"given":"Aysha","family":"Najeeb","sequence":"first","affiliation":[{"name":"Department of Dermatology &amp; Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-8494","authenticated-orcid":false,"given":"Vishal","family":"Gaurav","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankhuri","family":"Dudani","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shukla","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Microbiology University College of Medical Sciences and Guru Teg Bahadur Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Venereology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"87","article-title":"Chronic mucocutaneous candidiasis: a spectrum of genetic disorders","volume":"4","author":"Nahum A","year":"2017","journal-title":"LymphoSign J"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof2010004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.10.022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02570"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.723532"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-21279-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/aam.aam_54_18"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_483_19"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.04.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2016.71"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000516743"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091983"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5731"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3893"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312665"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1285887"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01376-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030700"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00690.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T14:29:39Z","timestamp":1749133779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/pde.15736"],"URL":"https:\/\/doi.org\/10.1111\/pde.15736","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"type":"print","value":"0736-8046"},{"type":"electronic","value":"1525-1470"}],"subject":[],"published":{"date-parts":[[2024,9,10]]},"assertion":[{"value":"2024-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}