{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:19:58Z","timestamp":1778498398208,"version":"3.51.4"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report on a 13\u2010year\u2010old boy diagnosed with hypohidrotic ectodermal dysplasia (HED) due to a pathogenic variant in ectodysplasin A (<jats:italic>EDA<\/jats:italic>). He exhibited multiple whitish, millimetric papules clustered on the nasal ala, forehead, temporal, and zygomatic arch areas. Histological examination revealed numerous hyperplastic sebaceous lobules within the upper dermis. The occurrence of sebaceous papules in this distribution among HED patients has rarely been reported. An association with the blockage of the Wnt\/\u03b2\u2010catenin pathway due to <jats:italic>EDA<\/jats:italic> malfunction has been speculated.<\/jats:p>","DOI":"10.1111\/pde.15751","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T06:54:11Z","timestamp":1725864851000},"page":"655-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Facial Sebaceous Hyperplasia in an Adolescent With Hypohidrotic Ectodermal Dysplasia"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1075-5103","authenticated-orcid":false,"given":"Elena Luc\u00eda","family":"Pinto\u2010Pulido","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-8536","authenticated-orcid":false,"given":"Lucero","family":"Noguera\u2010Morel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6859-187X","authenticated-orcid":false,"given":"Isabel","family":"Colmenero","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-6916","authenticated-orcid":false,"given":"Antonio","family":"Torrelo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7260-8718","authenticated-orcid":false,"given":"\u00c1ngela","family":"Hern\u00e1ndez\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"e_1_2_1_5_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102695"},{"key":"e_1_2_1_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.01.004"},{"key":"e_1_2_1_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.2003.05480.x"},{"key":"e_1_2_1_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.08.010"},{"key":"e_1_2_1_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15397"},{"key":"e_1_2_1_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(97)70082\u20103"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pde.15751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T06:45:58Z","timestamp":1751525158000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pde.15751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,8]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/pde.15751"],"URL":"https:\/\/doi.org\/10.1111\/pde.15751","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,8]]},"assertion":[{"value":"2024-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}