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We describe a case of severe pediatric HS and UC that were poorly controlled despite several standard\u2010of\u2010care therapies, including infliximab and ustekinumab. Transitioning the patient to upadacitinib monotherapy resulted in clinical improvement of both her UC and HS within 3\u2009months, and she was then able to be weaned off her other systemic therapies. While upadacitinib is not currently FDA\u2010approved for HS or pediatric UC, this case report shows promise for upadacitinib monotherapy for both of these complex inflammatory disorders.<\/jats:p>","DOI":"10.1111\/pde.15759","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T04:25:28Z","timestamp":1726028728000},"page":"353-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Successful Use of Upadacitinib as Monotherapy for Hidradenitis Suppurativa and Ulcerative Colitis in the Setting of Refractory Disease"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6333-8891","authenticated-orcid":false,"given":"Meryem T.","family":"Ok","sequence":"first","affiliation":[{"name":"Department of Medicine The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-3548","authenticated-orcid":false,"given":"Paul B.","family":"Googe","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-4637","authenticated-orcid":false,"given":"Christopher J.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Burkhart","sequence":"additional","affiliation":[{"name":"Burkhart Pediatric &amp; Adolescent Dermatology  Cary North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-6369","authenticated-orcid":false,"given":"Ajay S.","family":"Gulati","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Pathology and Laboratory Medicine The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-1053","authenticated-orcid":false,"given":"Elizabeth L.","family":"Nieman","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"issue":"7","key":"e_1_2_7_2_1","first-page":"814","article-title":"Overall and Subgroup Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa","volume":"154","author":"Garg A.","year":"2018","journal-title":"Journal of the American Medical Association Dermatology"},{"issue":"9","key":"e_1_2_7_3_1","first-page":"1022","article-title":"Association of Hidradenitis Suppurativa With Inflammatory Bowel Disease","volume":"155","author":"Chen W.\u2010T.","year":"2019","journal-title":"Journal of the American Medical Association Dermatology"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16677"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15404"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326390"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.04.058"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S391356"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13449"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00377-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754211049711"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1124628"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59040801"},{"key":"e_1_2_7_14_1","article-title":"Considering a Janus Kinase Inhibitor in Patients With Concomitant Ulcerative Colitis and Hidradenitis Suppurativa\/Acne Inversa: Is It Really a Gamble? 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